声动力疗法介导肿瘤细胞死亡模式的研究进展  

Tumor cell death model mediated by sonodynamic therapy

作　　者：王晓东 程文[1] WANG Xiaodong;CHENG Wen(Department of Ultrasound,Harbin Medical University Cancer Hospital,Harbin 150081,China)

机构地区：[1]哈尔滨医科大学附属肿瘤医院超声科,黑龙江哈尔滨150081

出　　处：《医学影像学杂志》2023年第6期1108-1111,共4页Journal of Medical Imaging

基　　金：国家自然科学基金资助项目(编号:81873900),黑龙江省自然科学基金重点项目(编号:ZD2021H005)。

摘　　要：声动力疗法(sonodynamic therapy,SDT)是一种新兴的非侵入性肿瘤治疗手段,其机制是声敏剂在低频超声辐照下产生细胞毒性因子,诱导肿瘤细胞死亡。相较于其他肿瘤治疗手段,超声具有聚集性高、穿透性强、安全方便等优势。SDT主要通过诱导肿瘤细胞凋亡实现治疗肿瘤的目的。随着研究进展,越来越多的细胞死亡方式被发现。同时发现SDT可以诱导肿瘤细胞发生多种细胞死亡模式。本文在对现有研究回顾的基础上,系统阐述了细胞凋亡、坏死、自噬、铁死亡、焦亡、坏死性凋亡的内在机制,以及SDT基于声敏剂种类的不同或者联合其他药物,如何诱导肿瘤细胞发生不同的死亡模式,以增强SDT的治疗效果、避免肿瘤多药耐药性问题、寻找新的SDT治疗靶点,实现多种细胞死亡模式联合治疗肿瘤,大大提升SDT疗效,同时为未来新型声敏剂的研究以及SDT联合治疗提供研究方向。Sonodynamic therapy(SDT)is a new type of non-invasive tumor therapy methods.The mechanism of SDT is that sonosensitizers produce a lot of cytotoxic factors and induce tumor cell death under low-frequency ultrasound irradiation.Compared with other tumor treatment methods,the advantages of SDT include high aggregation,strong penetration,safety and convenience.SDT achieves the purpose of tumor treatment by inducing tumor cell apoptosis.With the progress of research,more and more ways of cell death have been found.At the same time,it is found that SDT could induce a variety of cell death patterns in tumor cells.Based on the review of existing studies,this paper systematically expounds the internal mechanisms of apoptosis,necrosis,autophagy,ferroptosis,pyroptosis and necroptosis,and how SDT can induce different death modes of tumor cells based on different types of sound sensitizers or in combination with other drugs,so as to enhance the therapeutic effect of SDT,to avoid the problem of tumor multidrug resistance,and find new therapeutic targets for SDT,to realize the combination of multiple cell death modes in the treatment of tumor,to greatly improve the efficacy of SDT,and to provide a research direction for the future research of new sonosensitizers and SDT combined therapy.

关 键 词：声动力疗法 细胞凋亡 坏死性凋亡 肿瘤 

分 类 号：R73-36[医药卫生—肿瘤] R445.1[医药卫生—临床医学]