乳腺导管内原位癌伴微浸润的病理和免疫组织化学特征分析  

Pathological and immunohistochemical characteristics of breast ductal carcinoma in situ with microinvasion

作　　者：刘晓鑫 伏玉 LIU Xiaoxin;FU Yu(Department of Pathology,Yingkou Central Hospital,Yingkou,Liaoning,115000,China)

机构地区：[1]营口市中心医院病理科,辽宁营口115000

出　　处：《当代医学》2022年第36期46-49,共4页Contemporary Medicine

摘　　要：目的分析乳腺导管内原位癌伴微浸润(DCIS-MI)的病理和免疫组织化学特征。方法选取2018年10月至2021年3月本院收治的78例DCIS-MI患者作为研究组,另选取同期于本院就诊的78例乳腺导管内原位癌(DCIS)患者作为对照组。两组均行病理及免疫组织化学检查,分析病理及免疫组织化学特征。结果研究组病理分型以粉刺型为主,细胞核分级高级别占比较高,组织坏死情况较多;对照组病理分型以非粉刺型为主,细胞核分级低级别占比最高,组织坏死情况较少;研究组粉刺型、组织坏死占比高于对照组,细胞核分级优于对照组,差异有统计学意义(P<0.05)。两组雌激素受体(ER)、孕激素受体(PR)、人表皮生长因子受体(HER-2)阳性率比较差异无统计学意义;研究组Ki-67高表达占比高于对照组(P<0.05)。结论DCIS-MI患者相较于未伴微浸润的DCIS患者具有较为明显的病理与免疫组织化学特征,利于临床医生明确疑似DCIS-MI患者病情,可为临床诊治提供参考依据,值得临床推广应用。Objective To analyze the pathological and immunohistochemical characteristics of ductal carcinoma in situ with microinvasion(DCIS-MI)of the breast.Methods 78 patients with DCIS-MI admitted to our hospital from October 2018 to March 2021 were selected as the study group,and 78 patients with breast ductal carcinoma in situ(DCIS)admitted to our hospital during the same period were selected as the control group.The pathological and immunohistochemical characteristics of the two groups were analyzed.Results The pathological classification of the study group was mainly comedo type,with the relatively high proportion of high-grade nuclear grade and more tissue necrosis;in the control group,the pathological classification was mainly non-comedonal,the proportion of low grade nuclear grade was the highest,and tissue necrosis was less;the proportion of comedones and tissue necrosis in the study group was higher than that in the control group,and the nuclear grading was better than that in the control group,and the differences were statistically significant(P<0.05).There were no significant differences in the positive rates of estrogen receptor(ER),progesterone receptor(PR)and human epidermal growth factor receptor(HER-2)between the two groups;the proportion of high expression of Ki-67 in the study group was higher than that in the control group(P<0.05).Conclusion DCIS-MI patients have more obvious pathological and immunohistochemical characteristics compared with DCIS patients without microinvasion,which is helpful for clinicians to clarify the condition of patients with suspected DCIS-MI,and can provide reliable reference for clinical diagnosis and treatment,which is worthy of clinical promotion and application.

关 键 词：乳腺导管内原位癌 微浸润 病理 免疫组织化学特征 

分 类 号：R737.9[医药卫生—肿瘤]