小剂量盐酸普萘洛尔对食管胃底静脉曲张再出血的预防效果  

Preventive effect of low dose propranolol hydrochloride on rebleeding of esophageal and gastric varices

作　　者：周海生 黎振兴 王帆影 ZHOU Haisheng;LI Zhenxing;WANG Fanying(Department of Internal Medicine,Anyuan District People's Hospital,Pingxiang,Jiangxi,337000,China)

机构地区：[1]萍乡市安源区人民医院内科,江西萍乡337000

出　　处：《当代医学》2022年第33期168-170,共3页Contemporary Medicine

摘　　要：目的探讨小剂量盐酸普萘洛尔对食管胃底静脉曲张出血(EGVB)患者再出血的预防效果。方法选取2016年5月至2020年5月本院收治的60例EGVB患者作为研究对象,按随机数字表法分为两组,各30例。对照组给予组织胶或硬化剂,观察组在对照组基础上加用小剂量盐酸普萘洛尔,比较两组临床疗效、不良反应、再出血率及治疗前后肝功能指标。结果观察组治疗总有效率为96.67%,高于对照组的73.33%,差异有统计学意义(P<0.05);治疗后,观察组血清总胆红素(TBIL)、丙氨酸氨基转移酶(ALT)及天冬氨酸氨基转移酶(AST)水平均低于对照组(P<0.05);观察组不良反应发生率为3.33%,低于对照组的30.00%,差异有统计学意义(P<0.05);观察组治疗后12个月再出血率为6.67%,低于对照组的30.00%,差异有统计学意义(P<0.05)。结论小剂量盐酸普萘洛尔治疗EGVB疗效显著,可有效减少不良反应,降低再出血率,改善患者肝功能。Objective To investigate the preventive effect of small dose propranolol hydrochloride on rebleeding in patients with esophageal and gastric variceal bleeding(EGVB).Methods 60 patients with EGVB admitted to our hospital from May 2016 to May 2020 were selected as research subjects,and they were divided into two groups according to random number table method,with 30 cases in each group.The control group was given tissue glue or sclerosing agent,and the observation group was given small dose propranolol hydrochloride on the basis of the control group.The clinical efficacy,adverse reactions,rebleeding rate and liver function indexes before and after treatment were compared between the two groups.Results The total effective rate in the observation group was 96.67%,higher than 73.33% in the control group,the difference was statistically significant(P<0.05);After treatment,the levels of serum total bilirubin(TBIL),alanine aminotransferase(ALT)and aspartate aminotransferase(AST)in the observation group were lower than those in the control group(P<0.05).The incidence of adverse reactions in the observation group was 3.33%,which was lower than 30.00% in the control group,the difference was statistically significant(P<0.05);The rebleeding rate was 6.67% in the observation group 12 months after treatment,which was lower than 30.00% in the control group(P<0.05).Conclusion Low dose propranolol hydrochloride is effective in the treatment of EGVB,which can effectively reduce adverse reactions,reduce the rate of rebleeding,and improve the liver function of patients.

关 键 词：小剂量 盐酸普萘洛尔 食管胃底静脉曲张 再出血 预防效果 不良反应 

分 类 号：R571[医药卫生—消化系统]