低剂量奥氮平联合丙戊酸镁治疗双相情感障碍患者疗效  

The efficacy of low-dose olanzapine in combination with magnesium valproate in patients with bipolar disorder

作　　者：江连 刘新章 罗素娟 JIANG Lian;LIU Xinzhang;LUO Sujuan(Department of Psychiatry,Third People's Hospital of Yichun,Yichun,Jiangxi,336000,China;Department of Hematology and Rheumatology,Yichun People's Hospital,Yichun,Jiangxi,336000,China)

机构地区：[1]宜春市第三人民医院精神科女一病区,江西宜春336000 [2]宜春市人民医院血液风湿科,江西宜春336000

出　　处：《当代医学》2022年第32期9-13,共5页Contemporary Medicine

摘　　要：目的探讨低剂量奥氮平联合丙戊酸镁治疗双相情感障碍患者的疗效。方法选取2017年4月至2020年4月本院收治的双相情感障碍患者60例作为研究对象,按照简单随机法分为A组与B组,各30例。A组给予低剂量奥氮平联合丙戊酸镁治疗,B组单独给予丙戊酸镁治疗,比较两组临床疗效、不良反应发生率、贝克-拉范森躁狂量表(BRMS)、汉密尔顿抑郁量表(HAMD)、威斯康星卡片分类测验(WCST)评分、血清白蛋白(Alb)、总胆红素(TBIL)水平。结果A组治疗总有效率为93.33%,高于B组的70.00%,差异有统计学意义(P<0.05)。两组BRMS评分、HAMD评分、WCST测试组间、时间、交互比较差异有统计学意义(P<0.05)。治疗前,两组BRMS、HAMD、WCST评分比较差异无统计学意义;治疗2周、1个月后,两组BRMS评分、HAMD评分、WCST测试中随机错误数、持续错误数均低于治疗前,WCST测试中正确数、完成分类数均高于治疗前,且A组BRMS评分、HAMD评分、WCST测试中随机错误数、持续错误数低于B组,WCST测试中正确数、完成分类数高于B组,差异有统计学意义(P<0.05)。两组血清Alb、TBIL水平组间、时间、交互比较差异有统计学意义(P<0.05)。治疗前,两组血清Alb、TBIL水平比较差异无统计学意义;治疗2周、1个月后,两组血清Alb、TBIL水平均高于治疗前,且A组高于B组,差异有统计学意义(P<0.05)。两组不良反应发生率比较差异无统计学意义。结论应用低剂量奥氮平联合丙戊酸镁治疗双相情感障碍患者可缓解躁狂症状与抑郁情况,提高认知功能与机体抗氧化能力,提升疗效,且安全性高。Objective To investigate the efficacy of low-dose olanzapine combined with magnesium valproate in the treatment of patients with bipolar disorder.Methods Atotal of 60 patients with bipolar disorder admitted to our hospital fromApril 2017 toApril 2020 were selected as the research subjects,and they were divided into groupAand group B according to simple randomization,with 30 cases in each group.GroupAwas given low-dose olanzapine plus magnesium valproate,and group B was given magnesium valproate alone,the clinical efficacy,incidence of adverse effects,Baker-Lavanson mania scale(BRMS),Hamilton depression scale(HAMD),Wisconsin Card classification test(WCST)scores,serum albumin(Alb),and total bilirubin(TBIL)levels were compared between two groups.Results The total effective rate of treatment in groupAwas 93.33%,which was higher than 70.00%in group B,and the difference was statistically significant(P<0.05).There were significant differences in BRMS score,HAMD score,WCST test between the two groups of inter-group,time and interaction(P<0.05).Before treatment,there were no significant differences in BRMS,HAMD andWCST scores between the two groups;after 2 weeks and 1 month of treatment,the BRMS score,HAMD score,the number of random errors and persistent errors in theWCST test in the two groups were lower than those before treatment,the number of correct errors and the number of completed classifications in theWCST test were higher than those before treatment,and the BRMS score,HAMD score,the number of random errors and persistent errors in theWCST test in the group Awere lower than those in the group B.In theWCST test,the number of correct and completed classifications in group B were higher than those in group B,and the difference was statistically significant(P<0.05).There were significant differences of serum Alb and TBIL levels between the two groups of inter-group,time and interaction(P<0.05).Before treatment,there was no significant difference in serumAlb and TBIL levels between the two groups;after 2 weeks and 1 m

关 键 词：奥氮平 丙戊酸镁 双相情感障碍 

分 类 号：R749.4[医药卫生—神经病学与精神病学]