文拉法辛合并认知心理治疗难治性抑郁症的临床疗效  

Clinical efficacy of venlafaxine combined with cognitive psychotherapy in the treatment of refractory depression

作　　者：马庆尧 张冬梅 MAQingyao;ZHANG Dongmei(Department of Psychology,The Third Hospital of Dandong,Dandong,Liaoning,118003,China;Department of Psychiatry,Dandong Third Hospital,Dandong,Liaoning,118003,China)

机构地区：[1]丹东市第三医院心理三科,辽宁丹东118003 [2]丹东市第三医院精神三科,辽宁丹东118003

出　　处：《当代医学》2022年第29期11-14,共4页Contemporary Medicine

摘　　要：目的观察文拉法辛合并认知心理治疗难治性抑郁症的临床疗效。方法选取2019年3月至2020年12月本院收治的60例难治性抑郁症患者作为研究对象,随机分为两组,每组30例。对照组采用文拉法辛治疗,观察组在对照组基础上合并认知心理治疗。比较两组抑郁程度、不良反应发生率、生命质量及睡眠质量。结果治疗后2、4、6、8周,观察组汉密尔顿焦虑症量表(HAMD)评分均低于对照组,差异有统计学意义(P<0.05);观察组不良反应发生率低于对照组,差异有统计学意义(P<0.05);治疗后,观察组物质生活、社会功能、心理功能、躯体功能评分均高于对照组,差异有统计学意义(P<0.05);观察组睡眠效率、睡眠时间、入睡时间、日间功能、催眠药物、睡眠障碍、睡眠质量评分均低于对照组,差异有统计学意义(P<0.05)。结论文拉法辛合并认知心理治疗难治性抑郁症患者效果显著,能减轻患者抑郁症状,减少不良反应的发生,提高患者生命质量及睡眠质量,值得临床推广应用。Objective To observe the clinical efficacy of venlafaxine combined with cognitive psychotherapy in the treatment of refractory depression.Methods A total of 60 patients with refractory depression admitted to our hospital from March 2019 to December 2020 were selected as the research subjects,and they were randomly divided into two groups,with 30 cases in each group.The control group was treated with venlafaxine,and the observation group was combined with cognitive psychotherapy on the basis of the control group.The degree of depression,incidence of adverse reactions,quality of life and quality of sleep were compared between the two groups.Results At 2,4,6 and 8 weeks after treatment,the scores of Hamilton depression scale(HAMD)in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The incidence of adverse reactions in observation group was lower than that in control group,and the difference was statistically significant(P<0.05).After treatment,the scores of material life,social function,psychological function and physical function in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The scores of sleep efficiency,sleep time,sleep time,daytime function,hypnotic drugs,sleep disorders and sleep quality in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusion Venlafaxine combined with cognitive psychotherapy has significant effect on patients with refractory depression,which can reduce the symptoms of depression,reduce the occurrence of adverse reactions,improve the quality of life and quality of sleep,and is worthy of clinical application.

关 键 词：文拉法辛 认知心理治疗 难治性抑郁症 生命质量 睡眠质量 

分 类 号：R749.4[医药卫生—神经病学与精神病学]