重组人碱性成纤维细胞生长因子治疗手足口病口腔溃疡患儿的效果  

Effects of recombinant human basic fibroblast growth factor in treatment of oral ulcer in children with hand-foot-mouth disease

作　　者：张秀英 董静 赵亚楠 ZHANG Xiuying;DONG Jing;ZHAO Yanan(7^(th) Infection Department of Kaifeng Children’s Hospital,Kaifeng 475000 Henan,China)

机构地区：[1]开封市儿童医院内七感染科,河南开封475000

出　　处：《中国民康医学》2023年第12期72-74,81,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察重组人碱性成纤维细胞生长因子治疗手足口病口腔溃疡患儿的效果。方法:回顾性分析2021年9月至2022年10月该院收治的85例手足口病口腔溃疡患儿的临床资料,根据不同治疗方式将其分为对照组(n=43)和研究组(n=42)。对照组给予常规治疗,研究组在对照组基础上增加重组人碱性成纤维细胞生长因子治疗,比较两组临床疗效、治疗前后疼痛程度[修订版WongBaker面部表情疼痛评估法(FPS-R)]评分、口腔溃疡愈合时间、平均止痛时间、住院时间、治疗前后血常规指标水平(白细胞计数、中性粒细胞百分比、淋巴细胞百分比)和治疗1周内不良反应发生率。结果:研究组治疗总有效率为95.24%(40/42),高于对照组的79.07%(34/43),差异有统计学意义(P<0.05);治疗2 h、1 d、3 d、5 d及1周后,两组FPS-R评分均低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05);研究组愈合时间、平均止痛时间和住院时间均短于对照组,差异有统计学意义(P<0.05);两组治疗前后白细胞计数、中性粒细胞百分比、淋巴细胞百分比比较,差异均无统计学意义(P>0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:在常规治疗基础上采用重组人碱性成纤维细胞生长因子治疗手足口病口腔溃疡患儿可提高治疗总有效率,缩短愈合时间、平均止痛时间和住院时间,降低疼痛程度评分,效果优于单纯常规治疗。Objective:To observe effects of recombinant human basic fibroblast growth factor in treatment of oral ulcer in children with hand-foot-mouth disease.Methods:The clinical data of 85 children with hand-foot-mouth disease and oral ulcer admitted to this hospital from September 2021 to October 2022 were retrospectively analyzed.According to different treatment methods,they were divided into control group(n=43)and study group(n=42).The control group was given routine treatment,while the study group was treated with recombinant human basic fibroblast growth factor on the basis of that of the control group.The clinical efficacy,the pain degree scores before and after the treatment[revised Wong-Baker faces pain sevision(FPS-R)],the oral ulcer healing time,the analgesic time,the hospitalization time,the blood routine index levels before and after the treatment(white blood cell count,neutrophil percentage,lymphocyte percentage),and the incidence of adverse reactions within 1 week of treatment were compared between the two groups.Results:The total effective rate of treatment in the study group was 95.24%(40/42),which was higher than 79.07%(34/43)in the control group,and the difference was statistically significant(P<0.05).After 2 h,1 d,3 d,5 d and 1 week of treatment,the FPS-R scores of the two groups were lower than those before the treatment,those in the study group were lower than those in the control group,and the differences were statistically significant(P<0.05).The healing time,the average analgesic time and the hospitalization time of the study group were shorter than those of the control group,and the differences were statistically significant(P<0.05).There were no significant differences in the white blood cell count,neutrophil percentage and lymphocyte percentage between the two groups before and after the treatment(P>0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:On the basis of the routine treatment,the recombinant human basic fibroblas

关 键 词：手足口病 口腔溃疡 患儿 重组人碱性成纤维细胞生长因子 疼痛 血常规 不良反应 

分 类 号：R781.5[医药卫生—口腔医学]