精神分裂症合并医院感染患者血清氧化应激指标表达水平及其临床意义  

Expression levels and clinical significance of serum oxidative stress indicators in patients with schizophrenia and hospital infection

作　　者：董艳松 DONG Yansong(Department of Clinical Laboratory of Shangqiu Second People’s Hospital,Shangqiu 476000 Henan,China)

机构地区：[1]商丘市第二人民医院检验科,河南商丘476000

出　　处：《中国民康医学》2023年第12期121-123,131,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:分析精神分裂症合并医院感染患者血清氧化应激指标表达水平及其临床意义。方法:回顾性分析2019年2月至2021年10月该院收治的183例精神分裂症患者的临床资料,根据是否合并医院感染分为感染组48例和未感染组135例,另选取该院同期100名健康体检者为对照组,比较三组血清总抗氧化能力(T-AOC)、过氧化氢酶(CAT)、一氧化氮(NO)、谷胱甘肽过氧化物酶(GSH-Px)水平,比较不同感染严重程度患者的血清T-AOC、CAT、NO、GSH-Px水平,采用受试者工作特征(ROC)曲线分析血清氧化应激指标水平对精神分裂症合并医院感染的诊断价值。结果:血清T-AOC、CAT、GSH-Px水平比较,感染组<未感染组<对照组,且重度感染<中度感染<轻度感染;血清NO水平比较,感染组>未感染组>对照组,且重度感染>中度感染>轻度感染,差异均有统计学意义(P<0.05)。ROC曲线分析结果显示,血清T-AOC、CAT、NO、GSH-Px水平诊断精神分裂症合并医院感染的曲线下面积(AUC)均>0.7,联合诊断的AUC最大,为0.913,诊断价值较高。结论:发生医院感染的精神分裂症患者血清T-AOC、CAT、NO、GSH-Px表达水平发生显著变化,临床可通过检测氧化应激指标水平来判断精神分裂症患者是否发生医院感染,并评估感染的严重程度。Objective:To analyze expression levels and clinical significance of serum oxidative stress indicators in patients with schizophrenia and hospital infection.Methods:A retrospective analysis was conducted on the clinical data of 183 patients with schizophrenia admitted to the hospital from February 2019 to October 2021.They were divided into infected group(48 cases)and non-infected group(135 cases)based on whether they were complicated with hospital infections.Another 100 healthy examinees from the same period were selected as control group.The levels of total antioxidant capacity(T-AOC),catalase(CAT),nitric oxide(NO),and glutathione peroxidase(GSH-Px)in the serum of three groups were compared.The serum levels of T-AOC,CAT,NO,and GSH-Px in the patients with different levels of infection severity were compared.The receiver operating characteristic(ROC)curve was used to analyzed the diagnostic value of serum oxidative stress indicator levels in the patients with schizophrenia complicated with hospital infection.Results:The comparison of serum T-AOC,CAT,and GSH-Px levels showed that the infected group<the non-infected group<the control group,and the severe infection<the moderate infection<the mild infection;the comparison of serum NO levels showed that the infection group>the non-infected group>the control group,and the severe infection>the moderate infection>the mild infection;and the differences were statistically significant(P<0.05).The ROC curve show that the AUCs of serum T-AOC,CAT,NO,and GSH-Px levels in the diagnosis of schizophrenia with hospital infection were all>0.7,and the AUC of combined diagnosis was the highest,that was 0.913,indicating the high diagnostic value.Conclusions:The serum expression levels of T-AOC,CAT,NO,and GSH-Px in the schizophrenia patients with hospital infections have significantly changed.Therefore,the clinical detection of oxidative stress levels can be used to determine whether hospital infections has developed in the schizophrenia patients and evaluate the severity of the infectio

关 键 词：精神分裂症 医院感染 谷胱甘肽过氧化物酶 过氧化氢酶 总抗氧化能力 

分 类 号：R749.3[医药卫生—神经病学与精神病学]