双歧杆菌四联活菌片联合Hp根除治疗Hp阳性功能性消化不良患者的效果  

Effects of Bifidobacterium quadruple viable tablets combined with Hp eradication in treatment of Hp positive functional dyspepsia

作　　者：张喜云 ZHANG Xiyun(Chinese Medicine Hospital of Puyang Diabetes Geriatrics Department,Puyang 457000 Henan,China)

机构地区：[1]濮阳市中医医院糖尿病老年病科,河南濮阳457000

出　　处：《中国民康医学》2023年第11期77-80,共4页Medical Journal of Chinese People’s Health

摘　　要：目的:观察双歧杆菌四联活菌片联合幽门螺杆菌(Hp)根除治疗Hp阳性功能性消化不良(FD)患者的效果。方法:选取2021年3月至2022年3月该院收治的86例Hp阳性FD患者进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各43例。对照组采用Hp根除治疗,观察组在对照组基础上给予双歧杆菌四联活菌片治疗,比较两组治疗前及治疗2、4周后临床症状积分和Hp转阴率,临床疗效,治疗前后胃肠动力指标水平,胃肠激素指标[促胃动素(MTL)、生长抑素(SS)、胃泌素(GAS)]水平及不良反应发生率。结果:治疗2、4周后,观察组临床症状积分低于对照组,差异有统计学意义(P<0.05);观察组Hp转阴率高于对照组,差异有统计学意义(P<0.05);观察组治疗总有效率为97.67%,高于对照组的79.07%,差异有统计学意义(P<0.05);治疗后,观察组胃排空时间短于对照组,胃窦收缩幅度大于对照组,胃窦收缩频率高于对照组,差异均有统计学意义(P<0.05);观察组MTL水平高于对照组,SS、GAS水平均低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:双歧杆菌四联活菌片联合Hp根除治疗Hp阳性FD患者,可减轻患者临床症状,提高Hp转阴率和临床疗效,促进胃肠蠕动,改善胃肠激素水平,其效果优于单纯Hp根除治疗。Objective:To observe effects of Bifidobacterium quadruple viable tablets combined with Helicobacter pylori(Hp)eradication in treatment of patients with Hp positive functional dyspepsia(FD).Methods:A prospective study was conducted on 86 patients with Hp-positive FD admitted to this hospital from March 2021 to March 2022.They were divided into control group and observation group according to the random number table method,43 cases in each group.The control group was treated with Hp eradication,while the observation group was treated with Bifidobacterium quadruple viable tablets on the basis of that of the control group.The clinical symptom scores and the Hp negative conversion rate after 2 and 4 weeks of treatment,the clinical efficacy,the gastrointestinal motility index levels before and after the treatment,the gastrointestinal hormone index levels[motilin(MTL),somatostatin(SS),gastrin(GAS)],and the incidence of adverse reactions were compared between the two groups.Results:After 2 and 4 weeks of treatment,the clinical symptom score of the observation group was lower than that of the control group,and the difference was statistically significant(P<0.05).The Hp negative rate of in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).The total effective rate of treatment in the observation group was 97.67%,which was higher than 79.07%in the control group,and the difference was statistically significant(P<0.05).After the treatment,the gastric emptying time of the observation group was shorter than that of the control group,the gastric antrum contraction amplitude was greater than that of the control group,the gastric antrum contraction frequency was higher than that of the control group,and the differences were statistically significant(P<0.05).The MTL level of the observation group was higher than that of the control group,the levels of SS and GAS were lower than those of the control group,and the differences were statistically significant(P<0.05).

关 键 词：双歧杆菌四联活菌片 幽门螺杆菌 功能性消化不良 胃肠动力 胃肠激素 Hp转阴率 不良反应 

分 类 号：R57[医药卫生—消化系统]