ISG15在恶性肿瘤中的作用及机制研究进展  

Research Progress on the Role and Mechanism of ISG15 in Malignant Tumors

作　　者：李葵娜 阳志军[1] Li Kuina;Yang Zhijun(Department of Gynecology,Guangxi Medical University Cancer Hos pital,Key Laboratory of Early Prevention and Treatment for Regional High Frequency T umor(Guangxi Medical University),Ministryof Education,Nanning 530021,China)

机构地区：[1]广西医科大学附属肿瘤医院妇科,区域性高发肿瘤早期防治研究教育部重点实验室(广西医科大学),南宁530021

出　　处：《华中科技大学学报（医学版）》2023年第3期409-412,430,共5页Acta Medicinae Universitatis Scientiae et Technologiae Huazhong

基　　金：国家自然科学基金资助项目(No.82060476);区域性高发肿瘤早期防治研究教育部重点实验室(广西医科大学)课题(No.GKEZZ202121)。

摘　　要：干扰素刺激基因15(interferon-stimulated gene15,ISG15)是最早发现的泛素样蛋白,在恶性肿瘤中显示出复杂的致癌或抗癌双重活性,然而其具体调控机制仍未阐明。近年来研究发现ISG15通过调控DNA复制分叉进程、自噬及线粒体功能、免疫微环境及靶蛋白的翻译后修饰等参与恶性肿瘤细胞的增殖、凋亡、侵袭转移、干细胞干性及耐药等,是潜在的诊断、预后标志物及治疗靶点。该文就ISG15调控恶性肿瘤发生发展作用机制的最新发现进行综述。Interferon-stimulated gene 15(ISG15),the first ubiquitin-like protein identified,shows complex dual oncogenic or anticancer activities in malignant tumors.However,its specific regula tory mechanisms remain elusive.Recent studies have re-vealed that ISG15 is a potential diagnostic and prognostic marker and therapeutic target by reg ulating DNA replica tion process,autophagy and mitochondrial function,immune microenvironment and post-translational modifications of target proteins,w hich ure involved in proliferation,apoptosis,invasion and metastasis,stem cell stemness and drug resistance of malignant tumor cells.In this paper,we review the recent findings on the mechanism of ISG15's role in regulating malignant tumorigenesis and deve lopment.

关 键 词：ISG15 恶性肿瘤 DNA复制叉 免疫微环境 转移 耐药 免疫治疗 

分 类 号：R730.3[医药卫生—肿瘤]