双歧杆菌四联活菌片治疗老年功能性消化不良的临床效果  

Clinical effect of bifidobacterium tetrad tablets in the treatment of functional dyspepsia in the aged

作　　者：廖莉[1] 王禾[1] LIAO Li;WANG He(Department of Gastroenterology,the First People′s Hospital of Yibin,Sichuan Province,Yibin 644000,China)

机构地区：[1]四川省宜宾市第一人民医院消化内科,644000

出　　处：《临床合理用药杂志》2023年第17期13-16,共4页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察双歧杆菌四联活菌片治疗老年功能性消化不良的临床效果。方法选取2018年10月—2021年1月宜宾市第一人民医院消化内科诊治的老年功能性消化不良患者160例,按随机数字表法分为观察组与对照组,各80例。对照组给予枸橼酸莫沙必利片及柴胡舒肝丸治疗,观察组在对照组基础上加用双歧杆菌四联活菌片治疗,2组患者均连续治疗4周。比较2组患者治疗前后胃肠道症状评定量表(GSRS)评分、汉密尔顿抑郁量表(HAMD)评分、功能性消化障碍生活质量问卷(FD-DQL)评分、肠道菌群及胃肠激素水平。结果治疗4周后,2组患者GSRS、HAMD评分低于治疗前,FD-DQL评分高于治疗前,且观察组降低/升高幅度大于对照组(P均<0.01);对照组患者粪便中双歧杆菌、肠杆菌、乳杆菌、肠球菌及酵母菌数量与治疗前比较差异均无统计学意义(P>0.05),观察组患者粪便中双歧杆菌及乳杆菌数量均高于治疗前及对照组(P<0.01),肠杆菌、肠球菌和酵母菌数量均低于治疗前及对照组(P<0.01);2组患者胃泌素、胃动素及胃促生长素水平均高于治疗前,且观察组高于对照组(P均<0.01)。结论双歧杆菌四联活菌片治疗老年功能性消化不良可缓解患者胃肠道症状,改善负性情绪,提高生活质量,调节肠道菌群,促进胃肠激素分泌。Objective To observe the clinical effect of bifidobacterium tetrad viable tablets in the treatment of functional dyspepsia in the aged.Methods A total of 160 elderly patients with functional dyspepsia diagnosed and treated in the Department of Gastroenterology of the First People′s Hospital of Yibin from October 2018 to January 2021 were selected and divided into observation group and control group according to random number table method,with 80 cases in each group.The control group was treated with mosapride citrate tablets and Chaihu Shugan pills,and the observation group was treated with bifidobacterium tetrad tablets on the basis of the control group.Both groups were treated continuously for 4 weeks.Gastrointestinal Symptom Rating Scale(GSRS)score,Hamilton Depression Scale(HAMD)score,Functional dyspepsia Quality of Life Questionnaire(FD-DQL)score,intestinal flora and gastrointestinal hormone levels were compared between the two groups before and after treatment.Results After 4 weeks of treatment,the GSRS and HAMD scores of patients in both groups were lower than those before treatment,the FD-DQL scores were higher than those before treatment,and the increase/decrease of the observation group were greater than the control group(all P<0.01);The number of Bifidobacterium,Enterobacteriaceae,Lactobacillus,Enterococcus and Yeast in the feces of patients in the control group had no significant difference compared with that before treatment(P>0.05).The number of Bifidobacterium and Lactobacillus in the feces of patients in the observation group were higher than that before treatment and the control group(P<0.01),while the number of Enterobacteriaceae,Enterococcus and Yeast in the feces of patients in the observation group were lower than those before treatment and the control group(P<0.01);The levels of gastrin,motilin and ghrelin in both groups were higher than those before treatment,and those in the observation group were higher than those in the control group(all P<0.01).Conclusion Bifidobacterium tetrad can rel

关 键 词：功能性消化不良 老年人 双歧杆菌四联活菌片 柴胡疏肝丸 枸橼酸莫沙必利片 治疗效果 

分 类 号：R57[医药卫生—消化系统]