丁苯酞治疗急性脑梗死伴非痴呆型认知功能障碍的临床效果  

Clinical effect of butylphthalein in the treatment of acute cerebral infarction with non-dementian cognitive dysfunction

作　　者：赖有连 罗聪丽 LAI Youlian;LUO Congli(Department of Neurology,the Second Hospital of Longyan,Fujian Province,Longyan 364000,China)

机构地区：[1]福建省龙岩市第二医院神经内科,364000

出　　处：《临床合理用药杂志》2023年第19期17-20,共4页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察丁苯酞治疗急性脑梗死伴非痴呆型认知功能障碍的临床效果。方法选取2019年8月—2021年12月龙岩市第二医院收治的急性脑梗死伴非痴呆型认知功能障碍患者108例,采取随机数字表法分为丁苯酞治疗组和常规治疗组,各54例。常规治疗组给予常规治疗,丁苯酞治疗组在常规治疗组基础上加用丁苯酞治疗,2组均治疗2周。比较2组临床疗效,治疗前后美国国立卫生研究院卒中量表(NIHSS)评分、日常生活能力(BI)评分、血清基质金属蛋白酶-2(MMP-2)、丙二醛(MDA)、内皮素-1(ET-1)水平及不良反应。结果丁苯酞治疗组总有效率为88.89%,高于常规治疗组的74.07%(χ^(2)=3.927,P=0.048)。治疗2周后,2组NIHSS评分较治疗前降低,BI评分较治疗前升高,且丁苯酞治疗组降低/升高幅度大于常规治疗组(P均<0.01);2组血清MMP-2、MDA及ET-1水平均低于治疗前,且丁苯酞治疗组低于常规治疗组(P均<0.01)。2组患者血常规、尿便常规、肝肾功能未发现异常改变。结论丁苯酞治疗急性脑梗死伴非痴呆型认知功能障碍具有较好的效果,可以改善患者神经功能,提高日常生活能力,调节血清MMP-2、MDA及ET-1水平,可获得更好的预后。Objective To observe the clinical effect of butylphthalein in the treatment of acute cerebral infarction with non-dementia cognitive dysfunction.Methods A total of 108 patients with acute cerebral infarction accompanied by non-dementia cognitive dysfunction admitted to the Second Hospital of Longyan from August 2019 to December 2021 ywere selected and divided into butylphthalein treatment group and conventional treatment group by random number table method,with 54 cases in each group.The conventional treatment group was given conventional treatment,and the butylphthalein treatment group was treated with butylphthalein on the basis of the conventional treatment group.Both groups were treated for 2 weeks.The clinical efficacy,national institutes of health stroke scale(NIHSS)score,ability of daily living(BI)score,serum matrix metalloproteinase-2(MMP-2),malondialdehyde(MDA)and endothelin-1(ET-1)levels before and after treatment and adverse reactions were compared between the 2 groups.Results The total effective rate of the butylphthalein treatment group was 88.89%,which was higher than 74.07%of the conventional treatment group(χ^(2)=3.927,P=0.048).After 2 weeks of treatment,NIHSS score of 2 groups were lower than before treatment,BI score were higher than before treatment,and the decrease/increase amplitude of butylphthalein treatment group was greater than conventional treatment group(P<0.01);Serum levels of MMP-2,MDA and ET-1 in 2 groups were lower than before treatment,and butylphthalein treatment group was lower than conventional treatment group(P<0.01).No abnormal changes were found in blood routine,urine and stool routine,liver and kidney function in 2 groups.Conclusion Butylphthalein has a good effect in the treatment of acute cerebral infarction with non-dementia-type cognitive dysfunction,which can improve the neurological function,improve the ability of daily living,regulate the serum levels of MMP-2,MDA and ET-1,and obtain a better prognosis.

关 键 词：急性脑梗死 非痴呆型认知功能障碍 丁苯酞 治疗效果 血清生物标志物 

分 类 号：R743.3[医药卫生—神经病学与精神病学]