上海市成年双生子健康生活方式与肥胖的关联研究  

A case-control study on the association between a healthy lifestyle and obesity among adult twins in Shanghai

作　　者：周荣飞 朱珍妮[2] 汪正园[2] 臧嘉捷[2] 贾晓东 吕筠[4] 李立明[4] 吴凡[1] Zhou Rongfei;Zhu Zhenni;Wang Zhengyuan;Zang Jiajie;Jia Xiaodong;Lyu Jun;Li Liming;Wu Fan(School of Public Health,Fudan University,Shanghai 200032,China;Shanghai Municipal Center for Disease Control and Prevention,Shanghai 200336,China;Shanghai Chemical Industry Park Medical Center,Shanghai 201507,China;Department of Epidemiology and Biostatistics,School of Public Health,Peking University,Beijing 100191,China)

机构地区：[1]复旦大学公共卫生学院,上海200032 [2]上海市疾病预防控制中心,上海200336 [3]上海化学工业区医疗中心,上海201507 [4]北京大学公共卫生学院流行病与卫生统计学系,北京100191

出　　处：《中华流行病学杂志》2023年第6期862-867,共6页Chinese Journal of Epidemiology

基　　金：卫生行业科研专项(201502006,201002007)。

摘　　要：目的分析上海市成年双生子健康生活方式的数量与超重/肥胖及腹型肥胖的关联。方法使用2017-2018年上海市双生子项目第二轮调查数据,通过病例对照的研究设计分析健康生活方式与肥胖的关联,并进一步利用双生子配对控制遗传等混杂因素。结果共纳入7864名(3932对)成年双生子。同卵双生子配对病例对照分析显示,与0~2种健康生活方式者相比,有3种和4~5种健康生活方式者患超重/肥胖的风险分别降低49%(OR=0.51,95%CI:0.28~0.93)和70%(OR=0.30,95%CI:0.13~0.69),患腹型肥胖的风险分别降低17%(OR=0.83,95%CI:0.44~1.57)和66%(OR=0.34,95%CI:0.14~0.80);并且每增加1种健康生活方式,患超重/肥胖的风险降低41%(OR=0.59,95%CI:0.42~0.85),患腹型肥胖的风险降低37%(OR=0.63,95%CI:0.44~0.90)。结论健康生活方式的数量与超重/肥胖及腹型肥胖均相关,数量越多,患病风险越低。Objective To investigate the associations between the numbers of healthy lifestyles and overweight/obesity and abdominal obesity in adult twins in Shanghai.Methods Based on the Shanghai Twin Registry System PhaseⅡsurvey data in 2017-2018,a case-control study was conducted to analyze the association between healthy lifestyles and obesity and further adjusted for confounders by a co-twin control study.Results A total of 7864 adult twins(3932 pairs)were included.In the co-twin case-control analysis for monozygotic twins,compared with participants with 0 to 2 healthy lifestyles,those with 3 and 4 to 5 healthy lifestyles had a 49%(OR=0.51,95%CI:0.28-0.93)and 70%(OR=0.30,95%CI:0.13-0.69)lower risk of overweight/obesity,respectively,and a 17%(OR=0.83,95%CI:0.44-1.57)and 66%(OR=0.34,95%CI:0.14-0.80)lower risk of abdominal obesity,respectively.For each additional healthy lifestyle,the risk of developing overweight/obesity was reduced by 41%(OR=0.59,95%CI:0.42-0.85),and the risk of developing abdominal obesity was reduced by 37%(OR=0.63,95%CI:0.44-0.90).Conclusion An increasing number of healthy lifestyles was associated with a marked decreased risk for both overweight/obesity and abdominal obesity.

关 键 词：超重 肥胖 双生子 病例对照研究 

分 类 号：R195[医药卫生—卫生统计学]