The preventive and therapeutic potential of native Brazilian fruits on colorectal cancer  

作　　者：Roberto de Paula do Nascimento Lívia Mateus Reguengo Ana Paula da Fonseca Machado Mario Roberto Marostica Junior 

机构地区：[1]University of Campinas,School of Food Engineering,Monteiro Lobato Street 80,13083-862,Campinas,S˜ao Paulo state,Brazil

出　　处：《Food Bioscience》2022年第2期55-72,共18页食品生物科学（英文）

基　　金：Special thanks to 1.Paula Januzzi Guedes,a self-employed design professional responsible for creating the figures,and 2.Red Iberomericana de Alimentos Autoctonos Subutilizados(ALSUB-CYTED,118RT0543);This study was partly funded by Conselho Nacional de Desenvolvimento Científico e Tecnol´ogico(CNPq)-Processes 140812/2019-9,403328/2016-0,and 301496/2019-6;3.Fundaç˜ao de Amparo`a Pesquisa do Estado de S˜ao Paulo(FAPESP)-Processes 15/50333-1,15/13320-9,17/23657-6,18/11069-5,19/25048-2,and 19/03228-9.

摘　　要：In the last years,colorectal cancer(CRC)has been increasing substantially in developing countries.While the consumption of fat and meat have been linked with increased CRC risk,fruits intake can be protective.In addition,since CRC’s chemotherapy may be accompanied with adverse effects,natural plant products have been postulated as alternative or complementary therapeutic options.Brazilian fruits are rich sources of bioactive compounds,mainly phenolic compounds,with antioxidant,anti-inflammatory,and anticancer benefits,thus,future candidates for CRC management.Therefore,this narrative review aims to present and discuss the potential of native Brazilian fruits(e.g.,açaí,cocoa,jaboticaba,passionfruit)on CRC.Experimental studies performed from 2001 to present were considered.Polyphenol-rich powders and extracts from Brazilian fruits are the most promising products for CRC management.Studies with açaí(Euterpe oleracea)and cocoa(Theobroma cacao)are more numerous and their effects on CRC models in vitro and in vivo are demonstrated with more complexity in terms of molecular mechanisms.The main signaling pathways modulated by the effects of native Brazilian fruits,so far studied on CRC,are associated with:1.apoptosis(B-cell lymphoma 2-and caspase 3-related proteins),2.inflammation(pro-inflammatory interleukins and enzymes),and 3.oxidative stress(antioxidant enzymes).In addition,adhesion molecules and nuclear factor kappa B have been shown to be downregulated,which can interfere positively in several cellular processes,including proliferation,angiogenesis,and migration.The investigation of signaling pathways of great relevance for CRC initiation and progression is still necessary.

关 键 词：ANTHOCYANIN Bioactive compound CARCINOGENESIS Euterpe oleracea Phenolic compound Theobroma cacao 

分 类 号：R730.1[医药卫生—肿瘤]