Electrochemical C-H/N-H cross-coupling of 2-phenylindolizines with phenothiazines to synthesize novel N-aryl phenothiazine derivatives  

作　　者：Chenglong Feng Xin Liu Yuanbin She Zhenlu Shen Meichao Li 

机构地区：[1]College of Chemical Engineering,Zhejiang University of Technology,Hangzhou 310032,China

出　　处：《Chinese Chemical Letters》2023年第6期306-309,共4页中国化学快报（英文版）

基　　金：the generous financial support of the National Natural Science Foundations of China(Nos.22178321,21773211 and 21776260)。

摘　　要：A facile and elegant method for synthesis of novel N-aryl phenothiazine derivatives from 2-phenylindolizines and phenothiazines through direct electrochemical oxidation has been developed.This approach was performed smoothly at room temperature without external oxidant and catalyst.Cyclic voltammetry and in situ FTIR techniques were applied to analyze the cross-coupling process of phenothiazines and 2-phenylindolizines,which helped to select the appropriate reaction potential.Under the optimized conditions,a broad range of substrates were well tolerated,affording the desired products in moderate to excellent isolated yields(up to 91%)with high regioselectivity.Meanwhile,a plausible mechanism involving a radical pathway has been proposed.

关 键 词：N-Aryl phenothiazine derivatives Electrochemical oxidation 2-Phenylindolizines PHENOTHIAZINES CROSS-COUPLING 

分 类 号：O626.12[理学—有机化学]