PHENOTHIAZINES

作品数：9被引量：5H指数：1
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相关领域：医药卫生理学更多>>
相关作者：文芳谭节谭家镒梁巍黄牛更多>>
相关机构：武汉大学中国医学科学院北京协和医学院中国刑警学院扬州大学更多>>
相关期刊：《Science Bulletin》《Journal of Chinese Pharmaceutical Sciences》《Science China(Life Sciences)》《Acta Pharmacologica Sinica》更多>>
相关基金：国家自然科学基金更多>>
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Electrochemical C-H/N-H cross-coupling of 2-phenylindolizines with phenothiazines to synthesize novel N-aryl phenothiazine derivatives
《Chinese Chemical Letters》2023年第6期306-309,共4页Chenglong Feng Xin Liu Yuanbin She Zhenlu Shen Meichao Li 
the generous financial support of the National Natural Science Foundations of China(Nos.22178321,21773211 and 21776260)。
A facile and elegant method for synthesis of novel N-aryl phenothiazine derivatives from 2-phenylindolizines and phenothiazines through direct electrochemical oxidation has been developed.This approach was performed s...
关键词：N-Aryl phenothiazine derivatives Electrochemical oxidation 2-Phenylindolizines PHENOTHIAZINES CROSS-COUPLING 
Phenothiazine vs 5HT3 Antagonist Prophylactic Regimens to Prevent Post‐Anesthesia Care Unit Rescue Antiemetic: An Observational Study被引量：1
《Open Journal of Anesthesiology》2015年第2期27-32,共6页Joseph R. Ruiz Joe E. Ensor Jeffrey W. Lim Antoinette Van Meter Thomas F. Rahlfs 
Purpose: Our practitioners are asked to consider a patient’s postoperative nausea and vomiting (PONV) risk profile when developing their prophylactic antiemetic strategy. There is wide variation in employed strategie...
关键词：PHENOTHIAZINES 5HT3 Antagonists PROPHYLACTIC ANTIEMETICS PACU ANTIEMETIC Administration 
Potential antitumor mechanisms of phenothiazine drugs被引量：3
《Science China(Life Sciences)》2013年第11期1020-1027,共8页QI Lu DING YanQing 
In this study,three kinds of phenothiazine drugs were analyzed to explore their potential antitumor mechanisms.First,target proteins that could interact with chlorpromazine,fluphenazine and trifluoperazine were predic...
关键词：PHENOTHIAZINES ANTITUMOR BIOINFORMATICS target proteins 
Evaluation of the Anti-Trypanosoma cruzi Effects of the Antipsychotic Drug Levomepromazine
《International Journal of Clinical Medicine》2012年第5期344-351,共8页Inga Eva Stik Lange Elisabeth Mieko Furusho Pral Anahi Magdaleno Ariel Mariano Silber 
supported by grants from the Fundacao de Amparo a Pesquisa do Estado de Sao Paulo(FAPESP grant#11/50631-1 to AMS),Instituto Nacional de Biologia Estrutural e Química Medicinal em Doencas Infecciosas(INBEQMeDI);Conselho Nacional de Desenvolvimento Científico e Tecnológico(CNPq grant#470272/2011-2 to AMS).
Chagas disease, caused by the protozoan Trypanosoma cruzi, is a relevant parasitic disease in the Americas. Current chemotherapy relies on Nifurtimox and Benznidazole, which present serious drawbacks, including high t...
关键词：Chagas Disease PHENOTHIAZINES Trypanothione Reductase Amino Acid Metabolism CHEMOTHERAPY 
Theoretical Study on Thermodynamic Properties and Hydrophilicity of Polychorinated Phenothiazines (PCPTZs)
《Chinese Journal of Structural Chemistry》2011年第11期1575-1584,共10页陈斌媛 张学胜 李定龙 
The thermodynamic properties of 135 polychlorinated phenothiazines （PCPTZs） in the standard state are calculated using a combination of quantum mechanical computations performed with the Gaussian 03 program at the B...
关键词：polyehlorinated phenothiazines density functional theory （DFT） number and position of Cl atom substitution （Npcs） thermodynamic property HYDROPHILICITY 
Effects of phenothiazine drugs on serum levels of apolipoproteins and lipoproteins in schizophrenic subjects
《Acta Pharmacologica Sinica》2003年第10期1001-1005,1061,共6页文芳 谭节 
Projects supported by the Hubei Provincial Bureau of Science,№ 982P1503.
AIM: To investigate the risk factors and clinical significance of blood-lipid metabolic disorder in schizophrenic patients caused by phenothiazine treatment for long term(from 1 month to 25 years). METHODS: Serum leve...
关键词：SCHIZOPHRENIA PHENOTHIAZINES antipsychotic agents LIPOPROTEINS APOLIPOPROTEINS 
Structure-activity Relationship of Phenothiazines for Inhibition of Protein Kinase C and Reversal of Multidrug Resistance
《Journal of Chinese Pharmaceutical Sciences》2002年第2期11-18,共8页彭晖 杨纯正 齐静 梁巍 黄牛 郭宗儒 
ThisworkwassupportedbygrantsfromNSFCGeneralProject,GrantNo .394 70 816andNo .3990 0 186
Studies on structure-activity relationship of phenothiazines (PTZs) forinhibition of protein kinase C (PKC) and reversal of multidrug resistance (MDR) has been made invitro. The results showed that the order of potenc...
关键词：PHENOTHIAZINES multidrug resistance molecular modeling protein kinase C 
Kinetic studies on the single electron transfer reaction between 2, 2, 6, 6-tetramethylpiperidine oxoammonium ions and phenothiazines: the application of Marcus theory被引量：1
《Science China Chemistry》1999年第2期138-144,共7页吴隆民 郭霞 王隽 郭庆祥 刘中立 刘有成 
Project supported by the National Natural Science Foundation of China (Grant No. 29572047)
Electron transfer reactions take place readily between 2, 2, 6, 6-tetramethylpiperidine oxoammonium ions (la,lb) and phenothiazines (2a—2g), giving corresponding nitroxides (3a,3b) and phenothiazine radical cations ...
关键词：ELECTRON TRANSFER reaction PHENOTHIAZINE oxoammonium ion MARCUS theory. 
Modulating multidrug resistance through inhibiting of protein kinase C activity by phenothiazines
《Chinese Science Bulletin》1998年第14期1196-1200,共5页Wei Liang Chunzheng Yang Jing Qi Hui Peng Jianrong Duan Hanzhi Liu Dexian Zheng 
theNationalNaturalScienceFoundationofChina (GrantNo 394 70 816 )
In the present study, actions of phenothiazines(PTZ) in reversing multidrug resistance(MDR) and inhibiting PKC activity were investigated. It was found that the three PTZs caused 2.49, 36.58 and 75.78 fold reversal of...
关键词：PROTEIN KINASE C MULTIDRUG resistance PHENOTHIAZINES molecular modeling. 
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