Tetrapeptide self-assembled multicolor fluorescent nanoparticles for bioimaging applications  被引量:1

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作  者:Yuerong Wang Yang Lei Jiaye Wang Hui Yang Leming Sun 

机构地区:[1]School of Life Sciences,Key Laboratory of Space Bioscience&Biotechnology,Northwestern Polytechnical University,Xi’an 710072,China

出  处:《Chinese Chemical Letters》2023年第6期417-420,共4页中国化学快报(英文版)

基  金:supported by the National Natural Science Foundation of China(No.31900984);the Fundamental Research Funds for the Central Universities(No.D5000210899);Innovation and Entrepreneurship Fund from the Student Affairs Department of the Party Committee of Northwestern Polytechnic University(No.2021-CXCY-019)。

摘  要:The biocompatibility and biodegradability of peptide self-assembled materials makes them suitable for many biological applications,such as targeted drug delivery,bioimaging,and tracking of therapeutic agents.According to our previous research,self-assembled fluorescent peptide nanoparticles can overcome the intrinsic optical properties of peptides.However,monochromatic fluorescent nanomaterials have many limitations as luminescent agents in biomedical applications.Therefore,combining different fluorescent species into one nanostructure to prepare fluorescent nanoparticles with multiple emission wavelengths has become a very attractive research area in the bioimaging field.In this study,the tetrapeptide Trp-Trp-Trp-Trp(WWWW)was self-assembled into multicolor fluorescent nanoparticles(TPNPs).The results have demonstrated that TPNPs have the blue,green,red and near infrared(NIR)fluorescence emission wavelength.Moreover,TPNPs have shown excellent performance in multicolor bioimaging,biocompatibility,and photostability.The facile preparation and multicolor fluorescence features make TPNPs potentially useful in multiplex bioanalysis and diagnostics.

关 键 词:SELF-ASSEMBLY TETRAPEPTIDE MULTICOLOR Fluorescent nanoparticles BIOIMAGING 

分 类 号:TB383.1[一般工业技术—材料科学与工程] R318[医药卫生—生物医学工程]

 

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