One-step assembly of Pd-Keggin-polyoxometalates for catalytic benzothiadiazole generation and derived cell-imaging probe application  

作　　者：Xianqiang Huang Weilong Cui Sen Liu Gang Liu Yalin Zhang Zhihao Zhang Guodong Shen Zhen Li Jianyong Wang Yifa Chen 

机构地区：[1]Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology,School of Chemistry&Chemical Engineering,Liaocheng University,Liaocheng 252059,China [2]Key Laboratory of Biobased Material and Green Papermaking,Key Laboratory of Pulp&Paper Science and Technology of Shandong Province/Ministry of Education,Qilu University of Technology(Shandong Academy of Sciences),Ji’nan 250353,China [3]National and Local Joint Engineering Research Center of MPTES in High Energy and Safety LIBs,Engineering Research Center of MTEES(Ministry of Education),Key Lab.of ETESPG(GHEI),South China Normal University,Guangzhou 510006,China [4]Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials,Jiangsu Key Laboratory of New Power Batteries,School of Chemistry and Materials Science,Nanjing Normal University,Nanjing 210023,China

出　　处：《Chinese Chemical Letters》2023年第6期545-550,共6页中国化学快报（英文版）

基　　金：financially supported by National Natural Science Foundation of China(Nos.21871125,22171139,21801145 and 21901122);the Natural Science Foundation of Shandong Province,China(Nos.ZR2019MB043 and ZR2019QB022);Shandong Provincial Key R&D Program/Major Science and Technology Innovation Project of Shandong Province(No.2019JZZY020230);the Construction Project of Quality Curriculum for Postgraduate Education of Shandong Province(No.SDYKC19057)。

摘　　要：One-step assembly of organic-ligand modified Pd-Keggin-POMs has been rarely reported,so as for their applications in catalytic benzothiadiazole generation and derived cell-imaging probing.Herein,three PdKeggin-POMs(compounds 1-3)have been successfully synthesized via a one-step assembly strategy.Thus-obtained Pd-Keggin-POMs with well-defined structures and heterogeneous properties enable highly efficient catalytic benzothiadiazole generation.Specifically,compound 3 showed outstanding catalytic activities in Suzuki-Miyaura coupling reactions for the generation of benzothiadiazole derivatives(yields,90%-97%)and was represented as one of the best catalysts reported to date.Consequently,the obtained benzothiadiazoles were used as the bio-probe for tracking lipid droplets in living-cells and exhibited large Stokes shifts(130 nm),low cytotoxicity and good targeting,which could be also applied to mark the distribution of LDs in living He La cells.Systematic investigations clearly decipher the functions of PdKeggin-POMs toward finding novel bio-probe materials,highlighting a new insight into the generation of sustainable materials in life-science.

关 键 词：Metal-organic-pallidum-POMs Crystal structure SUZUKI-MIYAURA Fluorescent probe LDs 

分 类 号：Q503[生物学—生物化学] O626[理学—有机化学] O657.3[理学—化学]