复方聚乙二醇电解质散联合利那洛肽在肠道准备中的效果:一项临床随机对照研究  

Efficacy of Compound Polyethylene Glycol Electrolyte Powder Combined With Linaclotide in Bowel Preparation:A Clinical Randomized Controlled Study

作　　者：程佳琪 游云[2] 李丹[3] 聂占国[2] CHENG Jiaqi;YOU Yun;LI Dan;NIE Zhanguo(Xinjiang Medical University,Urumqi,830002;Department of Gastroenterology,General Hospital of Xinjiang Military Region,Urumqi;Shihezi University School of Medicine,Shihezi,Xinjiang Uygur Autonomous Region)

机构地区：[1]新疆医科大学,830002 [2]新疆军区总医院消化内科 [3]石河子大学医学院

出　　处：《胃肠病学》2022年第5期284-288,共5页Chinese Journal of Gastroenterology

摘　　要：背景:传统的肠道准备方案复方聚乙二醇电解质散(PEG)由于需要大量饮水而导致部分患者耐受性差,清洁效果有限,且影响观察视野,因此找到一种清洁力强、安全性高、大部分患者可接受的肠道清洁方法具有重要的临床意义。目的:探讨PEG联合利那洛肽在肠道准备中的效果和安全性。方法:将414例患者随机分为对照组(3 L PEG)、观察A组(3 L PEG+290μg利那洛肽)、观察B组(2 L PEG+290μg利那洛肽)。主要观察指标为根据波士顿肠道准备量表(BBPS)评分评估肠道准备的效果,次要观察指标为退镜时间、完成准备到结肠镜检查的时间间隔、患者并发症发生率、盲肠插管率以及息肉、腺瘤、痔疮、其他疾病检出率。同时对便秘亚组的BBPS评分进行分析。结果:观察A组恰当的肠道准备率、BBPS评分、息肉检出率、痔疮检出率等均显著高于对照组和观察B组(P<0.05),而观察B组与对照组相比无明显差异(P>0.05)。三组间盲肠插管率、结肠镜未完成率、其他疾病检出率、腺瘤检出率、退镜时间、完成准备到结肠镜检查的时间间隔、不良反应发生率均无明显差异(P>0.05)。观察A组便秘患者的BBPS评分显著高于对照组和观察B组便秘患者(P<0.05)。结论:利那洛肽作为肠道准备的辅助药物是安全有效的,3 L PEG联合利那洛肽可提高肠道清洁质量。The traditional bowel preparation compound polyethylene glycol electrolyte powder(PEG)has poor tolerance in some patients due to the need for a large amount of water,which has a limited cleaning effect and affects the visual field of observation.Therefore,it is of clinical significance to find a bowel cleaning method with strong cleaning power,high safety and is acceptable to most of the patients.Aims:To explore the efficacy and safety of PEG combined with linaclotide in bowel preparation.Methods:A total of 414 patients were randomly divided into 3 groups:control group(3 L PEG group),observation group A(3 L PEG+290μg linaclotide),observation group B(2 L PEG+290μg linaclotide).The primary outcome was the efficacy of bowel preparation based on the Boston bowel preparation scale(BBPS),the secondary outcomes were withdrawal time,time interval from preparation to colonoscopy,incidence of complications,cecal insertion rate,detection rates of polyps,adenoma,hemorrhoid and other diseases.BBPS score in constipation subgroup was analyzed.Results:The appropriate bowel preparation rate,BBPS score,and detection rates of polyps and hemorrhoid in observation group A were significantly higher than those in control group and observation group B(P<0.05),and no significant differences in above⁃mentioned indices were found between observation group B and control group(P>0.05).There were no significant differences in cecal insertion rate,incomplete colonoscopy rate,detection rates of adenoma and other diseases,withdrawal time,time interval from preparation to colonoscopy,and incidence of adverse reactions among the three groups(P>0.05).BBPS score in constipation patients in observation group A was significantly higher than that in observation group B and control group(P<0.05).Conclusions:Linaclotide is safe and effective as an adjuvant for bowel preparation.3 L PEG combined with linaclotide can improve the quality of bowel cleaning.

关 键 词：结肠镜检查 肠道准备 复方聚乙二醇电解质散 利那洛肽 随机对照试验 

分 类 号：R574.62[医药卫生—消化系统]