Efficient enantioselective synthesis of CF_(2)Hcontaining dispiro[benzo[b]thiophene-oxindolepyrrolidine]s via organocatalytic cycloaddition  

作　　者：Yabo Deng Yongzhen Li Yalan Wang Shuo Sun Sichao Ma Pengfei Jia Wenguang Li Kairong Wang Wenjin Yan 

机构地区：[1]The Institute of Pharmacology,School of Basic Medical Sciences,Lanzhou University,Lanzhou 730000,China

出　　处：《Organic Chemistry Frontiers》2022年第1期210-215,共6页有机化学前沿（英文）

基　　金：the National Natural Science Foundation of China(no.81872723 and 82073679).

摘　　要：An efficient and practical organocatalytic asymmetric[3+2]cycloaddition of difluoromethylated ketoimines and methyleneindolinones catalyzed by a quinine-derived squaramide has been disclosed.Under mild conditions,a broad range of CF_(2)H-containing dispiro[benzo[b]thiophene-oxindole-pyrrolidine]s bearing four adjacent chiral centers including two vicinal spiro quaternary stereocenters were obtained in high yields(up to 99%yield)with excellent diastereoselectivities(>20:1 dr,in all cases)and enantioselectivities(up to 99%ee).

关 键 词：CATALYTIC CENTERS SPIRO 

分 类 号：O62[理学—有机化学]