Efficient and selective extraction of sinomenine by deep eutectic solvents  

作　　者：Yunchang Fan Chunyan Zhu Sheli Zhang Lei Zhang Qiang Wang Feng Wang 

机构地区：[1]College of Chemistry and Chemical Engineering,Henan Polytechnic University,Jiaozuo 454003,China [2]College of Science and Technology,Jiaozuo Teachers College,Jiaozuo 454000,China

出　　处：《Chinese Journal of Chemical Engineering》2023年第5期109-117,共9页中国化学工程学报（英文版）

基　　金：financially supported by the National Natural Science Foundation of China ( 21307028);Foundation of Henan province (202102310614);the Fundamental Research Funds for the Universities of Henan Province (NSFRF210428);the Foundation of Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University (KJS2016)。

摘　　要：Sinomenine is the main bio-active ingredient of Sinomenii Caulis and usually produced by solventextraction techniques. However, the extraction of sinomenine suffers from the lack of highly efficient and environmentally-benign solvents. In this work, deep eutectic solvents(DESs) based on fragrances were synthesized, hydrogen-bond donors(HBDs) and hydrogen-bond acceptors(HBAs) components of DESs were identified and their extraction ability for sinomenine was evaluated and the extraction conditions were optimized by single-factor and orthogonal design experiments. It was found that the hydrogen-bonding interaction between sinomenine and DESs was the main extraction driving force and there was no explicit relationship between the extraction ability and the hydrophobicity of the DESs. The DESs could be recycled and sinomenine could be recovered quantitatively via backextraction. High-purity sinomenine((95.0 ± 2.3)%) could be produced. These findings suggest that DESs are highly-effective solvents for the isolation of sinomenine and exhibit great potential for the extraction of other bio-active compounds.

关 键 词：SINOMENINE Solvent extraction Deep eutectic solvent(DES) Hydrogen-bonding interaction REGENERATION PURIFICATION 

分 类 号：TQ460.6[化学工程—制药化工]