Synthesis of functionalized 3,2’-pyrrolidinyl spirooxindoles via domino 1,6-addition/annulation reactions of para-quinone methides and 3-chlorooxindoles  

作　　者：Xiaochen Tian Yongxing Zhang Weiwu Ren Yang Wang 

机构地区：[1]Molecular Synthesis Center&Key Laboratory of Marine Drugs,Chinese Ministry of Education,School of Medicine and Pharmacy,Ocean University of China,5 Yushan Road,Qingdao 266003,China [2]Laboratory for Marine Drugs and Bioproducts,Qingdao National Laboratory for Marine Science and Technology(QNLM),Qingdao 266237,China

出　　处：《Organic Chemistry Frontiers》2022年第3期615-626,共12页有机化学前沿（英文）

基　　金：We are thankful for financial support from OUC,QNLM(LMDBCXRC201902,LMDBCXRC201903),tsqn201909056,tsqn202103152.The project is supported by the Fundamental Research Funds for the Central Universities.

摘　　要：A highly efficient base-mediated diastereoselective[4+1]cycloaddition of ortho-tosylaminophenyl-substituted p-QMs with 3-chlorooxindoles has been developed to afford 3,2’-pyrrolidinyl spirooxindoles in high yields with high diastereoselectivity through a domino 1,6-addition/cyclization sequence.This reaction exhibits broad substrate scope and excellent functional group tolerance.

关 键 词：DOMINO functional SPIRO 

分 类 号：O62[理学—有机化学]