One-pot synthesis of natural-product inspired spiroindolines with anti-cancer activities  

作　　者：Shi-Qiang Li Wei Yan Liu-Jun He Ming Zhang Dian-Yong Tang Hong-yu Li Zhong-Zhu Chen Zhi-Gang Xu 

机构地区：[1]College of Pharmacy,National&Local Joint Engineering Research Center of Targeted and Innovative Therapeutics,IATTI,Chongqing University of Arts and Sciences,Chongqing 402160,China [2]Department of Pharmaceutical Sciences,College of Pharmacy,University of Arkansas for Medical Sciences,Little Rock,AR 72205,USA [3]Department of Internal Medicine,College of Medicine,University of Arkansas for Medical Sciences,Little Rock,AR 72205,USA [4]Cancer Center,Academy of Medical Sciences and Sichuan Provincial People’s Hospital,Affiliated Hospital of University of Electronic Science and technology of China,Chengdu,Sichuan 610000,China

出　　处：《Organic Chemistry Frontiers》2022年第3期682-686,共5页有机化学前沿（英文）

基　　金：The authors would like to thank the Science and Technology Research Program of Chongqing Municipal Education Commission(CXQT19029 and KJZD-M201801301);Science&Technology Department of Sichuan Province(2017FZ0084);the Natural Science Foundation Project of CQ CSTSC(cstc2018jszx-cyzdX0023 and cstc2021jcyj-bsh0233).We would also like to thank Ms H.Z.Liu and J.Xu for obtaining the HRMS and NMR data.

摘　　要：A post-Ugi/diastereoselective cascade reaction was developed to construct naturally existing spiroindolines via a facile and metal-free one-pot protocol.During the construction,a new C-C bond was formed through a selective 5-exo-dig indole cyclization on the propiolamide;and a new C-N bond was diastereoselectively formed which controlled the configuration of three chiral centers simultaneously.

关 键 词：synthesis SPIRO CENTERS 

分 类 号：O62[理学—有机化学]