Construction of axially chiral styrene-type allylamines via chiral phosphoric acid-catalyzed asymmetric reductive amination  

作　　者：You-Dong Shao Jin-Shuo Feng Dan-Dan Han Kang-Hui Pan Ling Zhang Yi-Fan Wang Zhong-Hui Ma Pei-Ru Wang Mingjing Yin Dao-Juan Cheng 

机构地区：[1]School of Chemistry and Chemical Engineering,Heze University,Heze 274015,China [2]School of Pharmacy,Anhui University of Chinese Medicine,Hefei 230012,China

出　　处：《Organic Chemistry Frontiers》2022年第3期764-770,共7页有机化学前沿（英文）

基　　金：We thank the National Natural Science Foundation of China(No.21602097 and 21601006)for financial support.Financial support from Heze University and Anhui University of Chinese Medicine is also gratefully acknowledged.

摘　　要：The first enantioselective synthesis of axially chiral styrene-type allylamines was achieved through chiral phosphoric acid mediated atroposelective reductive amination of 1-enal substituted 2-naphthols.This protocol features a broad substrate scope,good enantioselectivities(up to 90%ee)and mild reaction conditions,thus providing a new entry to the challenging atropisomeric acyclic styrene scaffolds.

关 键 词：STYRENE CHIRAL ALLYL 

分 类 号：O62[理学—有机化学]