Palladium-catalyzed stereoselective trifluoromethylated allylic alkylation of 3-substituted oxindoles  

作　　者：Dong Li Shuaibo Zhang Bangzhong Wang Wuding Sun Jinfeng Zhao Jingping Qu Yuhan Zhou 

机构地区：[1]State Key Laboratory of Fine Chemicals,Department of Pharmaceutical Sciences,School of Chemical Engineering,Dalian University of Technology,2 Linggong Road,Dalian 116024,China [2]State Key Laboratory of Fine Chemicals,School of Chemical Engineering,Dalian University of Technology,2 Linggong Road,Dalian 116024,China

出　　处：《Organic Chemistry Frontiers》2022年第3期810-815,共6页有机化学前沿（英文）

基　　金：Financial support for this work was provided by the National Natural Science Foundation of China(No.21878037);Science and Technology Innovation Fund of Dalian(No.2021JJ12GX025).We also acknowledge Prof.Baomin Wang,Dr Yuming Song,and Dr Ying Peng(Dalian University of Technology,China)for valuable discussions.

摘　　要：An efficient catalytic methodology for trifluoromethylated allylic alkylation of 3-substituted oxindoles usingα-(trifluoromethyl)alkenyl acetates as the trifluoromethyl-containing allylic alkylation partner is described.The reaction proceeds smoothly with the incorporation of Pd(OAc)_(2) and(R)-BINAP,affording various functionalized trifluoromethyl-containing 3,3’-disubstituted oxindoles with high yields and good enantioselectivities.

关 键 词：SUBSTITUTED ALKYLATION INDOLE 

分 类 号：O62[理学—有机化学]