2-Pyridinylmethyl borrowing:base-promoted C-alkylation of(pyridin-2-yl)-methyl alcohols with ketones via cleavage of unstrained C(sp^(3))-C(sp^(3))bonds  

作　　者：Chuan-Ming Hong Fei-Fei Zou Xin Zhuang Zhen Luo Zheng-Qiang Liu Li-Qing Ren Qing-Hua Li Tang-Lin Liu 

机构地区：[1]School of Chemistry and Chemical Engineering,Southwest University,Chongqing 400715,China

出　　处：《Organic Chemistry Frontiers》2022年第2期299-304,共6页有机化学前沿（英文）

基　　金：the financial support provided by the National Natural Science Foundation of China(21801209 and 21801210);the Fundamental Research Funds for the Central Universities(SWU118117,SWU118028 and XDJK2019AA003);the Venture&Innovation Support Program for Chongqing Overseas Returnees(cx2018085);the Natural Science Foundation of Chongqing,China(cstc2020jcyj-msxmX0130).

摘　　要：A transition metal-free synthesis of β-(pyridin-2-yl)-methyl ketones,using(pyridin-2-yl)methyl alcohols and ketones through the 2-pyridinylmethyl borrowing strategy,has been disclosed.This approach provides an efficient,available and environmentally benign access,leading to alkylation products with broad functional group tolerance and excellent yields.Meanwhile,the selective cleavage of unactivated C(sp^(3))-C(sp^(3))bonds of common secondary alcohols was achieved with high atom economy.

关 键 词：alcohols BONDS CLEAVAGE 

分 类 号：O62[理学—有机化学]