高危型人乳头瘤病毒、液基薄层细胞学检测在宫颈癌前病变筛查中的临床作用观察  

Observation on clinical role of combined high-risk human papillomavirus and thinprep cytologic test in the screening of cervical precancerous lesions

作　　者：刘丽丽 LIU Li-li(Department of Obstetrics and Gynecology,Tai'an Tourism Economic Development Zone Hospital,Tai'an 271000,China)

机构地区：[1]山东省泰安市旅游经济开发区医院妇产科,271000

出　　处：《中国实用医药》2023年第12期94-97,共4页China Practical Medicine

摘　　要：目的 分析高危型人乳头瘤病毒与液基薄层细胞学检测在宫颈癌前病变筛查中的作用。方法 74例宫颈病变患者为研究对象,均行高危型人乳头瘤病毒、液基薄层细胞学单独检测及联合检测,以组织病理学检查结果为金标准,分析三种检测方式的检测结果,对比三种检测方式的宫颈癌前病变检出情况及诊断效能。结果 组织病理学检查结果显示,74例宫颈病变患者中,21例为慢性宫颈炎,53例为宫颈癌前病变,占比为71.63%,其中宫颈上皮内瘤变1级21例、宫颈上皮内瘤变2级18例、宫颈上皮内瘤变3级14例。联合检测的宫颈癌前病变检出率高于高危型人乳头瘤病毒和液基薄层细胞学单独检测,差异有统计学意义(P<0.05)。联合检测的敏感性96.23%、特异性95.24%、准确性95.95%、阳性预测值98.08%和阴性预测值90.91%均明显高于高危型人乳头瘤病毒单独检测的75.47%、52.38%、68.92%、80.00%、45.83%和液基薄层细胞学单独检测的79.25%、61.90%、74.32%、84.00%、54.17%,差异均有统计学意义(P<0.05)。结论 应用高危型人乳头瘤病毒和液基薄层细胞学联合检测对宫颈癌前病变进行筛查,敏感性高,特异性高,存在推广价值。Objective To analyze the role of high-risk human papillomavirus and thinprep cytologic test in the screening of cervical precancerous lesions.Methods 74 patients with cervical lesions were studied,all of whom underwent high-risk human papillomavirus test and thinprep cytologic test alone and in combination,and the results of the three testing methods were analyzed using histopathological results as the gold standard to compare the detection of cervical precancerous lesions and the diagnostic efficacy of the three testing methods.Results The results of histopathological examination showed that among 74 patients with cervical lesions,21 cases had chronic cervicitis and 53 cases had cervical precancerous lesions,accounting for 71.63%,including 21 cases of cervical intraepithelial neoplasia grade 1,18 cases of cervical intraepithelial neoplasia grade 2,and 14 cases of cervical intraepithelial neoplasia grade 3.The detection rate of the combined test for cervical precancerous lesions was higher than that of the high-risk human papillomavirus test and thinprep cytologic test alone,and the difference was statistically significant(P<0.05).The sensitivity,specificity,accuracy,positive predictive value,positive predictive value and negative predictive value of combined test for cervical precancerous lesions were 96.23%,95.24%,95.95%,98.08%and 90.91%,which were significantly higher than those of high-risk human papillomavirus test(75.47%,52.38%,68.92%,80.00%and 45.83%)and thinprep cytologic test(79.25%,61.90%,74.32%,84.00%and 54.17%)alone,and the differences were statistically significant(P<0.05).Conclusion Combined high-risk human papillomavirus and thinprep cytologic test for the screening of cervical precancerous lesions has high sensitivity and specificity,and has the value of popularization.

关 键 词：高危型人乳头瘤病毒 液基薄层细胞学检测 宫颈癌前病变筛查 诊断效能 

分 类 号：R737.33[医药卫生—肿瘤]