制药工程中结晶分离智能技术的探究  

Research on the Intelligent Technology of Crystallization Separation in the Pharmaceutical Engineering

作　　者：朵芳芳 张明亮 丰贵鹏[2] 徐绍红[2] 陈改荣[3] 周建伟[1] 褚亮亮[1] 王储备[1] Duo Fangfang;Zhang Mingliang;Feng Guipeng;Xu Shaohong;Chen Gairong;Zhou Jianwei;Chu Liangliang;Wang Chubei(Xinxiang University,Henan Photoelectrocatalytic Material and Micro-nano Application Technology Academician Workstation,Xinxiang 453003,China;School of Pharmacy,Xinxiang University,Xinxiang 453003,China;School of Chemistry&Materials Engineering,Xinxiang University,Xinxiang 453003,China)

机构地区：[1]新乡学院河南省光电催化材料与微纳应用技术院士工作站,河南新乡453003 [2]新乡学院药学院,河南新乡453003 [3]新乡学院化学与材料工程学院,河南新乡453003

出　　处：《山东化工》2023年第9期186-188,共3页Shandong Chemical Industry

基　　金：新乡学院-四川大学新工科“智能+”制药工程虚拟教研室。

摘　　要：结晶在制药工业中是一个非常重要的分离单元操作,能够优化药品的品质。但是结晶过程是个复杂的过程,目前还没有成熟的机理模型来详细地描述整个结晶过程。人工智能被应用于各种科学和前沿技术,对于智慧制药生产的开发具有重要意义,它能够将现代的智能分析手段运用到结晶操作流程中。该研究通过对结晶过程分析,探究了过程分析技术和机器学习算法在结晶操作中的应用。为未来我国制药行业的智能化发展提供了重要的参考。As an important separation unit operation in the pharmaceutical process,crystallization can optimize the quality of drugs.However,the process of the crystallization is of complexity,and no mature mechanism model can be employed to describe the whole crystallization process in detail.Artificial intelligence has been applied in various scientific applications and advanced technologies.Therefore,it is of great significance for the exploration of the intelligent pharmaceutical production based on artificial intelligence,which can apply modern intelligent analysis methods to the crystallization process.This study explores the application of process analysis technology and machine learning algorithm in crystallization operation by analyzing the crystallization process,which provides an important reference for the intelligent development of Chinese pharmaceutical industry in the future.

关 键 词：制药工程 结晶 智能技术 过程分析技术 机器学习算法 

分 类 号：TQ460[化学工程—制药化工]