萎缩性舌炎患者血清维生素B12、叶酸水平分析  

Analysis of serum vitamin B12 and folate levels in patients with atrophic glossitis

作　　者：严佳敏 陈娟娟[1] YAN Jiamin;CHEN Juanjuan(Jiangxi Province Key Laboratory of Laboratory Medicine,Department of Clinical Laboratory,The Second Affiliated Hospital of Nanchang University,Nanchang 330006,China;Jiangxi Province Key Laboratory of Stomatological Biomedical Sciences,Department of Clinical Laboratory,The Affiliated Stomatological Hospital of Nanchang University,Nanchang 330006,China)

机构地区：[1]南昌大学第二附属医院检验科江西省检验医学重点实验室,江西南昌330006 [2]南昌大学附属口腔医院检验科江西省口腔生物医学重点实验室,江西南昌330006

出　　处：《实验与检验医学》2023年第2期123-126,共4页Experimental and Laboratory Medicine

基　　金：国家自然科学基金,编号81960497;江西省自然科学基金,编号20181BA215026;江西省卫健委课题,编号20201061。

摘　　要：目的研究维生素B12、叶酸在南昌地区萎缩性舌炎患者血清中的表达水平及其与萎缩性舌炎的关系,为萎缩性舌炎治疗提供参考。方法选取南昌大学附属口腔医院黏膜科2019年11月至2021年2月诊治的萎缩性舌炎患者72例为病例组,另选取来院行口腔体检的同年龄段正常人170例为对照组,采用化学发光法测定血清维生素B12和叶酸,同时收集病例组和对照组血细胞分析中MCV(红细胞平均体积)、HGB(血红蛋白)、RBC(红细胞数)三项指标进行分析。结果病例组MCV显著高于对照组(P<0.05),RBC和HGB显著低于对照组(P<0.05),三种指标差异有显著性。病例组维生素B12水平较对照组低,叶酸水平较对照组高,均有统计学差异(P<0.05)。口服维生素B12两周后疼痛指数及病损面积较初诊时显著降低,有统计学差异(P<0.05)。病例组维生素B12与叶酸呈负相关(P<0.05),对照组维生素B12与叶酸无相关性(P>0.05)。结论萎缩性舌炎患者维生素B12水平降低,叶酸水平升高,且维生素B12与叶酸水平呈负相关关系。维生素B12可以改善萎缩性舌炎患者的临床症状。Objective To study the expression levels of vitamin B12 and folic acid in the serum of patients with atrophic glossitis in Nanchang and their relationship with atrophic glossitis,so as to provide references for the treatment of atrophic glossitis.Methods A total of 72 patients with atrophic glossitis diagnosed and treated from November 2019 to February 2021 in the Mucosal Department of the Affiliated Stomatological Hospital of Nanchang University were selected as the case group,and 170 normal people of the same age who came to the hospital for oral physical examination were selected as the control group.Chemiluminescence method was used to determine serum vitamin B12 and folic acid.Three indicators of MCV(average red blood cell volume),HGB(hemoglobin)and RBC(red blood cell count)were collected for analysis of blood cell analysis in the case group and the control group.Results The MCV of the case group was significantly higher than that of the control group(P<0.05),and the RBC and HGB of the case group were significantly lower than that of the control group(P<0.05).The vitamin B12 level of the case group was lower than that of the control group,and the folic acid level was higher than that of the control group.There were statistical differences(P<0.05).The pain index and lesion area after two weeks of oral vitamin B12 treatment were significantly lower than those at initial diagnosis,with statistical differences(P<0.05).Vitamin B12 was negatively correlated with folic acid in the case group(P<0.05),and there was no correlation between vitamin B12 and folic acid in the control group(P>0.05).Conclusion The level of vitamin B12 in patients with atrophic glossitis is decreased,and the level of folic acid is increased,and there is a negative correlation between vitamin B12 and the level of folic acid.

关 键 词：萎缩性舌炎 维生素B12 叶酸 

分 类 号：R781.57[医药卫生—口腔医学]