肝衰竭患者预后预测研究进展  

Prognosis of patients with liver failure

作　　者：李顶春(综述) 游晶[1] 李武(审校)[1] Li Dingchun;You Jing;Li Wu(Department of Infectious Diseases and Liver Diseases,First Affiliated Hospital,Kunming Medical University,Kunming 650032,Yunnan Province,China)

机构地区：[1]昆明医科大学第一附属医院感染性疾病科,昆明市650032

出　　处：《实用肝脏病杂志》2023年第4期605-608,共4页Journal of Practical Hepatology

基　　金：国家自然科学基金资助项目(编号:81760111/81760617);国家科技重大专项课题SEARCH-B研究项目(编号:2012ZX10002003);云南省科技厅-昆明医科大学联合基金重点科研项目[编号:2017FE468(-173)];云南省“万人计划”名医专项[编号:云人卫发(2020)20号,RLMY20200015]。

摘　　要：目的肝衰竭是由各种因素导致的肝脏合成、解毒、代谢和生物转化等功能的严重损害。肝衰竭病因多样,预后极差,病死率极高。如何客观地评估肝衰竭的严重程度,提供适时的治疗方案非常重要。肝衰竭发病机制复杂,病情进展快,影响预后因素多,目前对肝衰竭患者预后研究成为一大热点。除了临床上应用较多的MELD评分、CTP评分、SOFA评分等外,许多肝衰竭预后评价体系和新的预后标记物被发现和挖掘。本文对肝衰竭预后评估的模型和评分进行了综述和介绍。Objective Liver failure(LF)is a serious syndrome with liver function,such as synthesis,detoxification,metabolism and biotransformation damages,caused by various factors.The causes of LF are diverse,the prognosis is extremely poor,and the mortality rate is extremely high.How to evaluate the severity of liver failure objectively and provide a timely and appropriate treatment plan for patients with LF is very important.The pathogenesis of LF is complicated,the disease progresses rapidly,and there are many factors affecting its prognosis.At present,the research on the prognosis has become a hot spot.In addition to the MELD score,CTP score,SOFA score,etc.,many prognostic evaluation systems and new prognostic markers have been discovered.In this article,we provide a review of models and scores for prognostic evaluation of patients with LF.

关 键 词：肝衰竭 预后 模型 评分 

分 类 号：R575.3[医药卫生—消化系统]