重视神经电生理检测在肌萎缩侧索硬化诊断中的作用  

Emphasize the role of electrophysiological measurements in the diagnosis of amyotrophic lateral sclerosis

作　　者：朱炬[1] 张哲成[1] ZHU Ju;ZHANG Zhecheng(Department of Neurology,Tianjin Third Central Hospital,Tianjin 300170,China)

机构地区：[1]天津市第三中心医院神经内科,300170

出　　处：《天津医药》2023年第7期673-676,共4页Tianjin Medical Journal

基　　金：天津市卫生健康科技项目(ZC20148)。

摘　　要：肌萎缩侧索硬化(ALS)是一种以上、下运动神经元丧失为特征的致死性神经退行性疾病,导致全身肌肉进行性无力萎缩,最终出现呼吸衰竭。神经电生理检测在ALS的早期诊断中发挥重要作用,甚至可以发现亚临床的功能障碍。神经传导和针极肌电图作为标准的神经电生理检测手段,对早期发现下运动神经元病变至关重要。一些用于估计运动单元数量的新兴技术可以提高诊断敏感度并用于评估疾病的进展。Amyotrophic lateral sclerosis(ALS)is a fatal neurodegenerative disease characterized by loss of upper and lower motor neurons,resulting in progressive weakness and wasting of all voluntary muscles,culminating in respiratory failure.Neuroelectrophysiological detection plays an an essential role in early diagnosis of ALS,and can even detect subclinical dysfunction.Nerve conduction and needle electromyography,as standard neurophysiological detection method,are very important for early detection of lower motor neuron disease.Many emerging techniques for estimating the number of motor units have been proposed to increase diagnostic sensitivities and used to assess ALS progression.

关 键 词：肌萎缩侧索硬化 电生理检测 神经传导 针极肌电图 

分 类 号：R746.4[医药卫生—神经病学与精神病学]