高速剪切—反相细乳液法制备负载氯沙坦淀粉纳米粒  

Preparation of losartan loaded starch nanoparticles by high-speed shear-inverse miniemulsion method

作　　者：段超 张昆明[1,2,3] 黄永春 郑建滨[1,2,3] 唐湘毅 DUAN Chao;ZHANG Kun-ming;HUANG Yong-chun;ZHENG Jian-bin;TANG Xiang-yi(School of Biological and Chemical Engineering,Guangxi University of Science and Technology,Liuzhou,Guangxi 545006,China;Guangxi Key Laboratory of Green Processing of Sugar Resources,Liuzhou,Guangxi 545006,China;Province and Ministry Co-sponsored Collaborative Innovation Center of Sugarcane and Sugar Industry,Nanning,Guangxi 530004,China)

机构地区：[1]广西科技大学生物与化学工程学院,广西柳州545006 [2]广西糖资源绿色加工重点实验室,广西柳州545006 [3]蔗糖产业省部共建协同创新中心,广西南宁530004

出　　处：《食品与机械》2023年第6期6-11,18,共7页Food and Machinery

基　　金：广西高等学校高水平创新团队及卓越学者计划项目(编号:桂教人[2014]7号);广西糖资源绿色加工重点实验室开放基金项目(编号:GXTZY201804);广西科技大学博士基金项目(编号:校科博21Z36)。

摘　　要：目的:探究高速剪切—反相细乳液交联法制备负载氯沙坦淀粉纳米粒的可行性。方法:以氯沙坦为模型药物、三偏磷酸钠为交联剂,考察淀粉溶液浓度、三偏磷酸钠添加量、交联时间和剪切速率对淀粉纳米粒粒径和产率的影响规律,并采用光学显微摄像仪、红外光谱仪、X射线衍射仪对负载氯沙坦淀粉纳米粒进行表征。结果:纳米粒制备的最佳工艺为淀粉溶液浓度15%,三偏磷酸钠添加量25%,交联时间3 h,剪切速率5 000 r/min,该条件下制得的纳米粒粒度最小为755.2 nm,产率可达69.5%;光学显微摄像显示纳米粒形态圆整,颗粒饱满且均为球形;FTIR显示氯沙坦成功负载于淀粉纳米粒中;XRD显示纳米粒以无定形结构存在。结论:高速剪切耦合反相细乳液交联法可以制备出小粒径的载药淀粉纳米粒。Objective:This study aimed to explore the feasibility of preparation of loaded losartan starch nanoparticles by high-speed shear-reverse microemulsion crosslinking.Methods:Using losartan as model drug and sodium trimetaphosphate as crosslinking agent,the effects of starch solution concentration,sodium trimetaphosphate addition amount,crosslinking time and shear rate on particle size and yield of starch nanoparticles were investigated.Optical micrography,infrared spectrometer and X-ray diffraction were used to characterize losartan loaded starch nanoparticles.Results:The optimal preparation process of nanoparticles was 15% starch solution concentration,25% sodium trimetaphosphate,3 h crosslinking time,5 000 r/min shear rate.Under the control of these conditions,the minimum size of nanoparticles was 755.2 nm,and the yield reached 69.5%.Optical micrography showed that the nanoparticles were round,full and spherical.FTIR showed that losartan was successfully loaded into starch nanoparticles.XRD showed that the nanoparticles exist in amorphous structure.Conclusion:Small particle size drug-carrying starch nanoparticles can be prepared by high-speed shear coupled reversed-phase fine emulsion crosslinking method.

关 键 词：反相细乳液法 高速剪切 淀粉纳米粒 三偏磷酸钠 氯沙坦 

分 类 号：TQ460.1[化学工程—制药化工]