垂体后叶素稀释液水垫在腹腔镜卵巢囊肿剔除术中的应用价值  

Clinical analysis of the effect of pituitrin in laparoscopic stripping of ovarian cystectomy

作　　者：胡盛霞 于晓辉 李桐 董潇霄 罗培 Hu Shengxia;Yu Xiaohui;Li Tong;Dong Xiaoxiao;Luo Pei(Department of Obstetrics and Gynecology,Affiliated Zhongshan Hospital Dalian University,Dalian 116001,China;Department of Gynecology,Dalian Medical University Affiliated Dalian Maternity Hospital,Dalian 116033,China;Department of Obstetrics and Gynecology,Dalian Hospital of Shengjing Hospital of China Medical University,Dalian 116100,China;Department of Obstetrics and Gynecology,Maternal and Child Health Care Hospital of Shangdong Province,Jinan 250014,China;Department of Obstetrics and Gynecology,Dalian Medical University,Dalian 116044,China)

机构地区：[1]大连大学附属中山医院妇产科,大连116001 [2]大连医科大学附属大连市妇产医院妇科,大连116033 [3]中国医科大学附属盛京医院大连医院妇产科,大连116100 [4]山东省妇幼保健院妇科,济南250014 [5]大连医科大学妇产科,大连116044

出　　处：《中国医师进修杂志》2023年第6期499-502,共4页Chinese Journal of Postgraduates of Medicine

基　　金：大连市卫健委课题(1711068)。

摘　　要：目的探讨垂体后叶素稀释液水垫在腹腔镜卵巢囊肿剔除术中应用价值。方法采用前瞻性研究的方法,收集大连医科大学附属大连市妇产医院2015年10月至2018年6月90例单侧卵巢良性囊肿(除外子宫内膜异位囊肿)患者按入院顺序依次分为研究组(垂体后叶素稀释液水垫组)、对照组1(无水垫常规手术组)、对照组2(0.9%氯化钠组),每组30例。研究组在卵巢皮质与囊肿壁间多点注射0.9%氯化钠稀释的6 U垂体后叶素10~20 ml,根据出血情况行点状缝合止血;对照组1行常规腹腔镜囊肿剔除、卵巢修补;对照组2在卵巢皮质与囊肿壁间多点注射0.9%氯化钠10~20 ml,止血方式同研究组。比较三组手术时间、术中出血量及手术前、术后3个月雌二醇(E2)、促卵泡生成素(FSH)、黄体生成素(LH)。结果研究组手术过程中的出血量明显少于对照组1[(14.00±5.48)ml比(18.33±6.99)ml],差异有统计学意义(P<0.05);研究组及对照组2手术时间均明显少于对照组1[(43.50±7.21)min、(45.00±10.29)min比(50.17±8.95)min],差异有统计学意义(P<0.05)。研究组及对照组2术后3个月FSH明显低于对照组1[(7.20±1.55)U/L、(7.43±1.52)U/L比(8.31±0.97)U/L],差异有统计学意义(P<0.05);研究组术后3个月E2水平明显高于对照组1及对照组2[(54.20±10.90)ng/L比(46.63±10.76)ng/L、(43.90±18.23)ng/L],差异有统计学意义(P<0.05);对照组1术后3个月LH与对照组2及研究组比较差异无统计学意义(P>0.05)。结论在腹腔镜卵巢囊肿剔除术中注射垂体后叶素稀释液水垫能减少囊肿剔除过程中的出血量及手术时间,同时能够减轻对卵巢储备功能的损害。Objective To discusse the value of pituitin in laparoscopic ovarian cyst removal.Methods From October 2015 to June 2018 in Dalian Medical University Affiliated Dalian Maternity Hospital,useing prospective research methods,90 patients with unilateral ovarian cyst(except endometriomas)were randomly divided in 3 groups of pituitrin group,control group 1 and control group 2.The pituitrin group:laparoscopic cystectomy with the injection of diluted pituitrin 6 U,the total amount of diluted pituitrin 10-20 ml,ovarian hemostasis was achieved by sutura.The control group 1:ordinary laparoscopic cystectomy without injection suture hemostasis.The control group 2:laparoscopic cystectomy with the injection of normal saline 10-20 ml,ovarian hemostasis was same to pituitrin group.The operation time and the amount of bleeding were compared among the three groups.The ovarian reserve was compared between before and 3 months after operation by estradiol(E2),follicle-stimulating hormone(FSH),luteinizing hormone(LH).Results The amount of bleeding in the pituitrin group was less than that in the control group1:(14.00±5.48)ml vs.(18.33±6.99)ml,P<0.05.The operation time in the pituitrin group and control group 2 was less than that in the control group1:(43.50±7.21)min,(45.00±10.29)min vs.(50.17±8.95)min,P<0.05.The level of FSH after operatiaon in the pituitrin group and control group 2 was less than that in the control group1:(7.20±1.55)U/L,(7.43±1.52)U/L vs.(8.31±0.97)U/L,P<0.05.The level of E23 months after operation in the pituitrin group was higher than that in the control group 1 and control group 2:(54.20±10.90)ng/L vs.(46.63±10.76)ng/L,(43.90±18.23)ng/L,P<0.05.There was no significant difference of LH 3 months after operation among the three groups(P>0.05).Conclusions This study shows that diluted pituitrin decreases operation time and the amount of bleeding during operation,at the same time,the pituitrin injection is valued of ovarian reserve.

关 键 词：腹腔镜 垂体激素类 后叶 卵巢囊肿剔除术 卵巢储备功能 

分 类 号：R737.31[医药卫生—肿瘤]