支链氨基酸型肠内营养制剂联合益生菌对肝硬化失代偿期患者肝功能指标的影响  

Effect of branched chain amino acid type enteral nutrition preparation combined with probiotics on liver function indicators in patients with decompensated liver cirrhosiss

作　　者：王翔宇 朱文艺 周洁 杜珊珊 何蔼 王建 WANG Xiangyu;ZHU Wenyi;ZHOU Jie;DU Shanshan;HE Ai;WANG Jian(Department of Nutrition,Second Affiliated Hospital of Army Military Medical University,Chongqing 400037,China;Department of Gastroenterology,Second Affiliated Hospital of Army Military Medical University,Chongqing 400037,China)

机构地区：[1]陆军军医大学第二附属医院营养科,重庆400037 [2]陆军军医大学第二附属医院消化内科,重庆400037

出　　处：《重庆医学》2023年第13期1970-1973,共4页Chongqing medicine

基　　金：陆军军医大学临床新技术2020年度准入项目(XJSZR0880)。

摘　　要：目的分析支链氨基酸(BCAA)型肠内营养制剂联合益生菌对肝硬化失代偿期患者肝功能的影响。方法选取2017年2月至2019年3月重庆某三甲医院消化内科病区收治的肝硬化失代偿期患者72例,采用随机数字表法分为研究组和对照组,每组36例。对照组仅给予肝硬化失代偿期饮食指导,研究组在相同饮食指导基础上给予BCAA型肠内营养制剂联合益生菌治疗。比较两组患者治疗前后清蛋白(ALB)、前清蛋白(PA)、丙氨酸氨基转移酶(ALT)、天门冬氨酸氨基转移酶(AST)、总胆红素(TBIL)和直接胆红素(DBIL)等相关指标变化。结果研究组患者干预后ALB水平明显高于对照组,差异有统计学意义(P<0.05);研究组患者干预前后ALB、PA变化幅度均明显大于对照组,差异均有统计学意义(P<0.05)。两组患者干预前后ALT、AST、TBIL、DBIL水平比较,差异均无统计学意义(P>0.05);研究组患者干预前后TBIL、DBIL变化幅度均明显大于对照组,差异均有统计学意义(P<0.05)。研究组患者干预前后肝功能相关指标均较干预前明显好转,差异均有统计学意义(P<0.05);对照组患者干预前后ALT、AST、TBIL、DBIL水平比较,差异均无统计学意义(P>0.05)。结论BCAA型肠内营养制剂联合益生菌用于肠内营养支持可明显改善失代偿期肝硬化患者ALB水平,同时也有助于减轻失代偿期肝硬化患者的肝功能负担。Objective To analyze the effect of branched chain amino acid(BCAA)type enteral nutrition preparation combined with probiotics on the liver function in the patients with decompensated liver cirrhosis.Methods Seventy-two patients with decompensated liver cirrhosis treated in the gastroenterology department of a class 3A hospital of Chongqing from February 2017 to March 2019 were selected and divided into the study group and control group by adopting the random number table method,36 cases in each group.The control group was only given the diet guidance during the decompensated period of liver cirrhosis,and the study group was given the BCAA enteral nutrition preparation combined with probiotics on the basis of the same diet guidance.The changes of serum albumin(ALB),prealbumin(PA),alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBIL)and direct bilirubin(DBIL)levels before and after treatment were compared between the two groups.Results The ALB level after the intervention in the study group was significantly better than that in the control group with statistical difference(P<0.05);the change range of ALB and PA before and after intervention in the study group was significantly greater than that in the control group,and the difference was statistically significant(P<0.05).The liver function related indicators after intervention in the study group were significantly improved compared with those before intervention,and the difference was statistically significant(P<0.05).ALT,AST,TBIL and DBIL in the control group had no statistical difference between before and after the intervention(P>0.05).Conclusion The enteral nutrition support of BCAA type enteral nutrition preparation combined with probiotic could significantly improve the ALB level in the patients with decompensated cirrhosis,meanwhile also help to reduce the burden of liver function in the patients with decompensated cirrhosis.

关 键 词：肝硬化失代偿期 支链氨基酸 益生菌 肠内营养 

分 类 号：R151.43[医药卫生—营养与食品卫生学]