老年帕金森病病人外周血ApoA1/HDL、血尿酸水平与认知功能的关系  

Relationship between Levels of Peripheral Blood ApoA1/HDL and Blood Uric Acid and Cognitive Function in Elderly Patients with Parkinson′s Disease

作　　者：杨一帆 高峰[2] 柳华 沈富伟 缪礁丹 YANG Yifan;GAO Feng;LIU Hua;SHEN Fuwei;MIAO Jiaodan(The Affiliated Hospital of Southwest Jiaotong University(Third People's Hospital of Chengdu),Chengdu 610000,Sichuan,China)

机构地区：[1]西南交通大学附属医院/成都市第三人民医院,成都610000 [2]西南交通大学

出　　处：《中西医结合心脑血管病杂志》2023年第13期2474-2478,共5页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

基　　金：四川省科技计划基金项目(No.2021JDR0343);成都市科技项目(No.2019-YF09-00086-SN)。

摘　　要：目的:探讨老年帕金森病(PD)病人外周血载脂蛋白A1与高密度脂蛋白比值(ApoA1/HDL)、尿酸(UA)水平与认知功能的关系。方法:选取2020年1月—2021年1月成都市第三人民医院门诊和住院部收治的120例老年PD病人作为研究对象(PD组),根据是否伴有认知障碍分为认知障碍组(68例)和认知正常组(52例),另外选取同期进行健康体检的50名老年人作为正常对照组。收集所有研究对象的临床资料,检测外周血ApoA1/HDL、UA水平,采用多因素Logistic回归分析PD病人认知障碍发生的危险因素,采用Pearson相关分析法分析外周血ApoA1/HDL、UA水平与认知功能的相关性。结果:PD组外周血ApoA1/HDL、UA水平低于正常对照组(P<0.001);认知障碍组高血脂比例高于认知正常组(P<0.001),受教育年限、外周血ApoA1/HDL、UA水平及蒙特利尔认知评估量表(MoCA)和简易智能精神状态检查量表(MMSE)评分低于认知正常组(P<0.001)。多因素Logistic回归分析显示,ApoA1/HDL、UA是PD病人认知障碍发生的危险因素(P<0.05);经Pearson相关分析显示,PD病人外周血ApoA1/HDL与MoCA评分、MMSE评分均呈正相关(P<0.05),UA与MoCA评分、MMSE评分也呈正相关(P<0.05)。结论:老年PD病人外周血ApoA1/HDL、UA水平明显降低,ApoA1/HDL、UA是PD病人认知障碍发生的危险因素,其外周血ApoA1/HDL、UA水平与认知功能呈正相关。Objective:To study the relationship between levels of peripheral blood apolipoprotein A1 to high density lipoprotein ratio(ApoA1/HDL)and uric acid(UA)and cognitive function in elderly patients with Parkinson's disease(PD).Methods:A total of 120 elderly patients with PD admitted to the outpatient and inpatient departments of the Third People's Hospital of Chengdu from January 2020 to January 2021 were selected as the research subjects(PD group),and divided into cognitive dysfunction group(n=68)and normal cognitive function group(n=52)according to the patients with or without cognitive dysfunction.Another 50 elderly people who underwent physical examination during the same period were included in the normal control group.The clinical data of all the subjects were collected,and the levels of peripheral blood ApoA1/HDL and UA were detected and compared.Multivariate Logistic regression was used to analyze the risk factors of cognitive dysfunction in patients with PD,and Pearson correlation analysis was applied to analyze the correlation between peripheral blood ApoA1/HDL and UA levels and cognitive function.Results:The levels of ApoA1/HDL and UA in peripheral blood of PD patients were lower than those of normal control group(P<0.001).The proportion of hyperlipidemia in PD patients in cognitive dysfunction group was higher than that in normal cognitive function group(P<0.001),and years of education,peripheral blood ApoA1/HDL,UA,Montreal Cognitive Assessment Scale(MoCA)score,and Min-i Mental State Examination(MMSE)score were lower than those in normal cognitive function group(P<0.001).Multivariate Logistic regression analysis showed that ApoA1/HDL and UA were the influencing factors of occurrence of cognitive dysfunction in patients with PD(P<0.05).Pearson correlation analysis revealed that ApoA1/HDL in peripheral blood of PD patients was significantly positively correlated with MoCA score and MMSE score(P<0.05),and UA was also significantly positive correlated with MoCA score and MMSE score(P<0.05).Conclusion:The level

关 键 词：帕金森病 载脂蛋白A1 高密度脂蛋白 血尿酸 认知功能 

分 类 号：R742.5[医药卫生—神经病学与精神病学]