乌司奴单抗治疗老年难治性溃疡性结肠炎1例  

Ustekinumab for treatment of refractory ulcerative colitis in an elderly patient:A case report

作　　者：萧绮莉 徐钰婷 Qi-Li Xiao;Yu-Ting Xu

机构地区：[1]广州中医药大学附属中山市中医院肛肠科,广东省中山市528400

出　　处：《世界华人消化杂志》2023年第12期515-520,共6页World Chinese Journal of Digestology

摘　　要：背景难治性溃疡性结肠炎在临床上表现为对多种药物无效或不耐受,病情反复发作,治疗存在一定困难.病例简介本例患者因“痔术后反复便血4月”来诊,诊断为溃疡性结肠炎,经多种药物治疗无效后,超适应症使用乌司奴单抗治疗显效,病情得以控制.结论难治性溃疡性结肠炎的诊疗不应拘泥于现有药物的用药适应证,综合国内外诊治经验及指南建议可拓宽诊疗思路,为该类患者带来获益.BACKGROUND Refractory ulcerative colitis is clinically irresponsive or intolerant to multiple drugs,with recurrent episodes and difficulties in treatment.CASE SUMMARY The patient in this case was diagnosed with ulcerative colitis due to repeated bloody stools for 4 mo after hemorrhoid surgery.After multiple drug treatment failures,the off-label treatment with ustekinumab was effective,and the patient’s condition was under control.CONCLUSION The diagnosis and treatment of refractory ulcerative colitis should not be limited to the indications of existing drugs.Integrating domestic and foreign medical experiences and guidelines can broaden the diagnosis and treatment approach and bring benefits to such patients.

关 键 词：难治性溃疡性结肠炎 乌司奴单抗 老年患者 超适应证用药 

分 类 号：R574.62[医药卫生—消化系统]