原位交联羧甲基壳聚糖/碳酸钙凝胶海绵的制备及其止血性能研究  

Preparation of in situ Crosslinked Carboxymethyl Chitosan/Calcium Carbonate Gel Sponge and Its Hemostatic Performance

作　　者：赵静 杨雪 苏晓雷 高欣伟 苏静 王鸿博 ZHAO Jing;YANG Xue;SU Xiao-lei;GAO Xin-wei;SU Jing;WANG Hong-bo(School of Textile Science and Engineering,Jiangnan University,Wuxi 214122,China;School of Food Science and Technology,Jiangnan University,Wuxi 214122,China)

机构地区：[1]江南大学纺织科学与工程学院,无锡214122 [2]江南大学食品学院,无锡214122

出　　处：《高分子通报》2023年第7期844-850,共7页Polymer Bulletin

基　　金：国家自然科学基金项目(52003108);中央高校基本科研业务费专项资金(JUSRP121027)资助。

摘　　要：以羧甲基壳聚糖(CMCS)、碳酸钙(CaCO3)、葡萄糖酸内酯(GDL)和甘油(GLY)为原料,通过原位相转变制备水凝胶,经冷冻干燥工艺得到止血海绵,用于躯体非压迫性出血。通过扫描电镜、吸水率、孔隙率、溶血实验和全血凝固时间测试分别对海绵的理化性能、血液安全性、止血性能进行研究。当CaCO3与CMCS的质量比为15%时,制得的海绵综合性能最好。该海绵呈疏松多孔片层状,止血时间较医用棉纱布材料缩短了35%,无血液毒性,是一种优良的止血海绵材料。Using carboxymethyl chitosan(CMCS),calcium carbonate(CaCO3),glucolactone(GDL),glycerol(GLY)as raw materials,hydrogels were prepared by in situ phase transformation,and hemostatic sponges were obtained by freeze-drying process for body non compressive bleeding.The physical and chemical properties,blood safety and hemostatic properties of sponge were studied by scanning electron microscope analysis,water absorption analysis,porosity analysis,hemolysis test and whole blood coagulation time test.When the mass ratio of CaCO3 to CMCS is 15%,the prepared sponge shows the best comprehensive performance.The sponge is porous,and the hemostatic time is 35%shorter than that of medical cotton gauze.It shows no blood toxicity,which is an excellent hemostatic sponge material.

关 键 词：羧甲基壳聚糖 碳酸钙 葡萄糖酸内酯 海绵 止血 

分 类 号：R318.08[医药卫生—生物医学工程] TB34[医药卫生—基础医学]