左卡尼汀致进行性肌营养不良患者血压升高  

Elevation of blood pressure in a patient with progressive muscular dystrophy due to levocarnitine

作　　者：王飞[1] 刘刚[1] 殷卓林 张艳[1] Wang Fei;Liu Gang;Yin Zhuolin;Zhang Yan(Department of Neurology,Xuanwu Hospital,Capital Medical University,Beijing 100053,China;Department of Neurology,Jilin Provincial People′s Hospital,Changchun 130000,China)

机构地区：[1]首都医科大学宣武医院神经内科,北京100053 [2]吉林省人民医院神经内科,长春130000

出　　处：《药物不良反应杂志》2023年第6期374-375,共2页Adverse Drug Reactions Journal

摘　　要：1例23岁男性进行性肌营养不良症患者接受静脉注射用左卡尼汀1 g、2次/d。用药前血压120/70 mmHg(1 mmHg=0.133 kPa)。首次用药15 min后,患者血压升至156/90 mmHg,伴胸闷、头痛,4 h后升至196/138 mmHg,12 h后降至158/106 mmHg;当日第2次静脉注射左卡尼汀后,上述情况复现。考虑血压升高与左卡尼汀有关。次日停用该药,患者血压逐渐恢复至参考值范围。此后患者未再出现血压升高和胸闷、头痛等症状。A 23‑year‑old male patient with progressive muscular dystrophy received intravenous injection of levocarnitine 1 g twice daily.Before the medication,the patient′s blood pressure was 120/70 mmHg.After 15 minutes of the first administration,the patient′s blood pressure increased to 156/90 mmHg,accompanied by chest tightness and headache;4 hours later,it increased to 196/138 mmHg;12 hours later,it decreased to 158/106 mmHg.After the second intravenous injection of levocarnitine on the same day,the elevation of blood pressure recurred.The elevation of blood pressure was considered to be caused by levocarnitine.The drug was discontinued the next day,and the patient′s blood pressure gradually returned to the reference range.Thereafter,the patient did not experience any symptoms such as elevated blood pressure,chest tightness,or headache.

关 键 词：肌营养不良 高血压 左卡尼汀 

分 类 号：R969[医药卫生—药理学]