肺结节的病理演进与分子影像研究进展  

Advances in the pathological evolution of pulmonary nodules and molecular imaging studies

作　　者：张敏[1,2] 张国建[2,3] ZHANG Min;ZHANG Guojian(The First Clinical Medical College of Inner Mongolia Medical University,Hohhot 010050,China;Department of Nuclear Medicine,Affifiliated Hospital of Inner Mongolia Medical University,Hohhot 010050,China;Key Laboratory of Molecular Imaging,Inner Mongolia Autonomous Region,Hohhot 010050,China)

机构地区：[1]内蒙古医科大学第一临床医学院,内蒙古呼和浩特010050 [2]内蒙古医科大学附属医院核医学科,内蒙古呼和浩特010050 [3]内蒙古自治区分子影像学重点实验室,内蒙古呼和浩特010050

出　　处：《分子影像学杂志》2023年第4期759-764,共6页Journal of Molecular Imaging

基　　金：国家自然科学基金(81960319);内蒙古自然科学基金(2021MS08085);内蒙古自治区高等学校青年科技英才支持计划(NJYT22002);内蒙古医科大学致远人才计划(善学人才项目)(ZY0202037)。

摘　　要：随着肺部低剂量CT的普及和大众健康意识的提高,肺结节的检出率大大提高,但良恶性判断仍然是目前影像学的难点和热点,早期明确诊断对于疾病治疗方案的选择和预后结果至关重要。目前影像学对肺结节的研究已经从形态学向分子影像学方向发展,分子影像学能够对活体进行细胞和分子水平的定性、定量、动态研究,在诊断肺结节中显示出重要价值和潜力。本文就不同病理类型肺结节的病理演进过程进行概述,并对几种不同类型的核医学分子影像显像剂作一综述。As the prevalence of low-dose CT scans for the lungs continues to rise,coupled with the enhancement of public health awareness,there has been a significant surge in the detection rate of pulmonary nodules.However,discerning between benign and malignant cases remains a contemporary challenge and hot topic in radiology.It is crucial to establish an early definitive diagnosis for the proper selection of treatment plans and to anticipate prognosis outcomes.The current investigative focus in radiology concerning pulmonary nodules has evolved from morphology to molecular imaging.Molecular imaging is capable of conducting qualitative,quantitative,and dynamic studies at the cellular and molecular level in vivo,revealing its important value and potential in diagnosing pulmonary nodules.This paper provides an overview of the pathological progression of pulmonary nodules of different pathological types and reviews the latest research developments of several different types of nuclear medicine molecular imaging agents in pulmonary nodules.

关 键 词：肺结节 病理 分子影像学 核医学显像 

分 类 号：R734.2[医药卫生—肿瘤] R730.44[医药卫生—临床医学]