急性胰腺炎肠道微生态的研究现状与进展  

Current status and advancements in research of gut microecology in acute pancreatitis

作　　者：贾锋 李风 白凯淞 邹小龙[2,3] Feng Jia;Feng Li;Kai-Song Bai;Xiao-Long Zou(Duerbote County Hospital of Traditional Chinese Medicine,Daqing 163000,Heilongjiang Province,China;Key Laboratory of Intensive Care Medicine,Qunli Branch,The First Affiliated Hospital of Harbin Medical University,Harbin 150081,Heilongjiang Province,China;Department of Hepatobiliary and Pancreatic Surgery,Qunli Branch,The First Affiliated Hospital of Harbin Medical University,Harbin 150081,Heilongjiang Province,China)

机构地区：[1]杜尔伯特县中医医院,黑龙江省大庆市163000 [2]哈尔滨医科大学第一附属医院群力院区肝胆胰外科,黑龙江省哈尔滨市150081 [3]哈尔滨医科大学第一附属医院群力院区重症医学重点实验室,黑龙江省哈尔滨市150081

出　　处：《世界华人消化杂志》2023年第13期521-527,共7页World Chinese Journal of Digestology

摘　　要：急性胰腺炎(acute pancreatitis,AP)是临床最常见的急腹症之一,其发病率正逐年升高,给医疗卫生系统带来沉重的负担.近年来随着高通量测序技术的进步,大量研究数据显示AP病程中益生菌和条件致病菌及其代谢产物失衡,并且肠道屏障破坏和菌群移位是AP全身炎症反应加重和后期感染性并发症的重要原因.维持患者肠道微生态稳定,可能有助于预防AP导致的肠源性感染和“二次打击”,从而改善患者预后.本文对肠道微生态及菌群代谢产物在AP病程中的作用以及潜在治疗策略进行了系统回顾,希望为深入理解AP疾病机制和寻找新的治疗靶点提供参考.Acute pancreatitis(AP)is one of the most common acute abdominal conditions in clinical practice,with increasing incidence and substantial healthcare burden.In recent years,substantial research with high-throughput sequencing technologies has revealed the imbalance between beneficial and pathogenic microbiomes as well as their metabolites during the clinical course of AP.Furthermore,disruption of the intestinal barrier and microbial translocation have been identified as important factors exacerbating systemic inflammatory response and subsequent infectious complications in AP.Maintaining a stable gastrointestinal microecology in patients may help prevent gut-derived infection and attenuate the“second hit”of inflammation induced by AP,thereby improving patient outcomes.This article provides a systematic review of the role of intestinal microbiota and microbial metabolites in the progression of AP,as well as potential therapeutic strategies,in order to offer insights into the understanding of AP pathogenesis and the identification of novel therapeutic targets.

关 键 词：急性胰腺炎 肠道微生态 细菌移位 

分 类 号：R576[医药卫生—消化系统]