外周血CA72-4、CA15-3、SCC检测在肺癌患者术前分期和预后评估中的应用价值  

Application Value of Detection of CA72-4,CA15-3 and SCC in Peripheral Blood in Preoperative Staging and Prognosis Evaluation of Patients with Lung Cancer

作　　者：王圆美 邹标 WANG Yuanmei;ZOU Biao(First People's Hospital of Fuzhou,Jiangxi Province,Fuzhou 344000,China)

机构地区：[1]江西省抚州市第一人民医院,江西抚州344000

出　　处：《中国医学创新》2023年第19期141-145,共5页Medical Innovation of China

摘　　要：目的:探讨外周血糖类抗原(CA)72-4、CA15-3、鳞癌相关抗原(SCC)检测在肺癌(LC)患者术前分期和预后评估中的应用价值。方法:选取2019年2月—2021年2月在抚州市第一人民医院接受手术治疗的LC患者62例,采用化学发光法检测患者术前外周血CA72-4、CA15-3、SCC表达情况,分析CA72-4、CA15-3和SCC阳性表达与LC患者术前分期的关系。术后跟踪随访2年,记录LC患者预后情况,分析CA72-4、CA15-3和SCC表达在预后评估中的应用,并采用多因素Cox回归模型分析影响LC患者预后的危险因素。结果:62例LC患者共检出CA72-4阳性25例(40.32%),CA15-3阳性19例(30.65%),SCC阳性29例(46.77%)。肿瘤分期为Ⅲ期和有淋巴结转移患者的CA72-4、CA15-3和SCC阳性检出率均高于肿瘤分期为Ⅰ期和无淋巴结转移的LC患者,差异均有统计学意义(P<0.05)。Ⅲ期SCC阳性检出率高于Ⅱ期,Ⅱ期CA72-4阳性检出率高于Ⅰ期(P<0.05)。生存结果显示,CA72-4、CA15-3和SCC阳性表达患者的生存率和无病生存率均显著低于CA72-4、CA15-3和SCC阴性表达患者,差异均有统计学意义(P<0.05)。Cox回归分析显示,CA72-4阳性(HR=1.887)、CA15-3阳性(HR=1.853)和SCC阳性(HR=1.876)均为影响LC患者预后的独立危险因素(P<0.05)。结论:外周血CA72-4、CA15-3、SCC与LC患者术前分期密切相关,且可用于评估患者术后预后。Objective:To explore the application value of detection of carbohydrate antigen(CA)72-4,CA15-3 and squamous cancinoma-associated antigen(SCC)in peripheral blood in preoperative staging and prognosis evaluation of patients with lung cancer(LC).Method:A total of 62 patients with LC who received surgical treatment in First People's Hospital of Fuzhou from February 2019 to February 2021 were selected.The expression of CA72-4,CA15-3 and SCC in peripheral blood of patients before surgery was detected by chemiluminescence,and the relationship between the positive expression of CA72-4,CA15-3 and SCC and the preoperative staging of LC patients were analyzed.Follow-up for 2 years after surgery,the prognosis of LC patients was recorded,the application of CA72-4,CA15-3 and SCC expression in prognosis assessment was analyzed,and the risk factors affecting the prognosis of LC patients was analyzed by multivariate Cox regression model.Result:A total of 25(40.32%)were positive for CA72-4,19(30.65%)were positive for CA15-3,and 29(46.77%)were positive for SCC of the 62 LC patients.The positive detection rates of CA72-4,CA15-3 and SCC in patients with tumor stagingⅢand lymph node metastasis were higher than those with tumor stagingⅠand lymph node non-metastasis,the difference were statistically significant(P<0.05).The positive detection rate of SCC in stageⅢwas higher than that in stageⅡ,and the positive detection rate of CA72-4 in stageⅡwas higher than that in stageⅠ(P<0.05).Survival results showed that the survival rate and disease free survival rate of patients with CA72-4,CA15-3 and SCC positive expression were significantly lower than those with CA72-4,CA15-3 and SCC negative expression,the differences were statistically significant(P<0.05).Cox regression analysis showed that CA72-4 positive(HR=1.887),CA15-3 positive(HR=1.853)and SCC positive(HR=1.876)were independent independent risk factors influencing the prognosis of LC patients(P<0.05).Conclusion:Peripheral blood CA72-4,CA15-3 and SCC are closely related to th

关 键 词：肺癌 糖类抗原72-4 糖类抗原15-3 鳞癌相关抗原 预后 

分 类 号：R734.2[医药卫生—肿瘤]