不同剂量阿托伐他汀钙对大脑中动脉狭窄患者脑血管储备能力的影响  

Effect of different doses of atorvastatin calcium on cerebrovascular reserve capacity in patients with middle cerebral artery stenosis

作　　者：刘晨阳 李金燕 LIU Chenyang;LI Jinyan(Xi'an Gaoxin Hospital,Xi'an 710075;521 Hospital of Norinco Group,Xi'an,Xi'an 710065,China)

机构地区：[1]西安高新医院,陕西西安710075 [2]西安·兵器工业五二一医院,陕西西安710065

出　　处：《临床医学研究与实践》2023年第20期29-32,共4页Clinical Research and Practice

摘　　要：目的探究不同剂量阿托伐他汀钙对大脑中动脉狭窄患者脑血管储备能力(CVR)的影响,为临床提供理论参考,以提高大脑中动脉狭窄的诊疗水平。方法选取2020年1月至12月在我院接受治疗的80例大脑中动脉狭窄患者为研究对象,采用随机数字表法将其分为对照组和观察组,各40例。两组均采用阿托伐他汀钙治疗,其中对照组10 mg/次、1次/d,观察组40 mg/次、1次/d。比较两组治疗前、后的CVR、血浆黏度(PV)、纤维蛋白原(FIB)水平、红细胞压积(HCT)及不良事件发生情况。结果治疗后,两组的CVR高于治疗前,且观察组高于对照组,差异具有统计学意义(P<0.05)。治疗后,两组的PV、FIB水平及HCT均低于治疗前,且观察组低于对照组,差异具有统计学意义(P<0.05)。观察组的不良事件总发生率略低于对照组,但差异无统计学意义(P>0.05)。结论阿托伐他汀钙口服辅助治疗大脑中动脉狭窄效果明显,适当增加剂量可更好地提升患者CVR,且不会增加不良事件。Objective To explore the effect of different doses of atorvastatin calcium on cerebrovascular reserve capacity(CVR)in patients with middle cerebral artery stenosis,and to provide theoretical reference for clinical practice,so as to improve the diagnosis and treatment level of middle cerebral artery stenosis.Methods A total of 80 patients with middle cerebral artery stenosis who received treatment in our hospital from January to December 2020 were selected as the study objects and divided into control group and observation group by random number table method,with 40 cases in each group.Both groups were treated with atorvastatin calcium,the control group received 10 mg/dose,once a day,and the observation group received 40 mg/dose,once a day.The CVR,plasma viscosity(PV),fibrinogen(FIB)level,hematocrit(HCT)before and after treatment and occurrence of adverse events were compared between the two groups.Results After treatment,The CVR of the two groups was higher than that before treatment,that in the observation group was higher than the control group,and the difference was statistically significant(P<0.05).After treatment,the PV,FIB level and HCT in the two groups were lower than those before treatment,those in the observation group were lower than the control group,and the differences were statistically significant(P<0.05).The total incidence of adverse events in the observation group was slightly lower than that in the control group,but the difference was not statistically significant(P>0.05).Conclusion Atorvastatin calcium oral adjuvant treatment for middle cerebral artery stenosis has obvious effect.Properly increasing the dosage can better improve the CVR of patients,and will not increase adverse events.

关 键 词：大脑中动脉狭窄 阿托伐他汀钙 脑血管储备能力 

分 类 号：R743.4[医药卫生—神经病学与精神病学]