Cyanation and cyanomethylation of trimethylammonium salts via electrochemical cleavage of C–N bonds  

作　　者：Xianqiang Kong Yuchang Wang Yiyi Chen Xiaohui Chen Long Lin Zhong-Yan Cao 

机构地区：[1]School of Chemical Engineering and Materials,Changzhou Institute of Technology,Changzhou 213032,China [2]College of Chemistry,Chemical Engineering and Biotechnology,Donghua University,2999 North Renmin Lu,Shanghai 201620,China [3]College of Chemistry and Chemical Engineering,Henan University,Kaifeng 475004,China

出　　处：《Organic Chemistry Frontiers》2022年第5期1288-1294,共7页有机化学前沿（英文）

基　　金：This work was supported by the National Natural Science Foundation of China(22102012);the Changzhou Science and Technology Plan Applied Basic Research Project(CJ20210159 and CJ20210129);Henan University.

摘　　要：We have developed a practical and mild electrochemical protocol for cyanation and cyanomethylation of trimethylammonium salts through a pathway involving C–N bond cleavage without the need for an exter-nal stoichiometric reducing agent or a sacrificial anode.The reaction employs tosyl cyanide(TsCN)or azido allyl alcohol as the cyanation or cyanomethylation reagent,respectively.It shows high functional group compatibility and can be applied for the cyanation of natural product derivatives.Preliminary mechanistic studies indicate the involvement of a radical addition pathway.

关 键 词：SALTS ammonium CLEAVAGE 

分 类 号：O62[理学—有机化学]