Boron-catalyzed α-C–H fluorination of aryl acetic acids  

作　　者：Haipeng Hu Cuilin Wang Xin Wu Yangu Liu Guizhou Yue Gehong Su Juhua Feng 

机构地区：[1]College of Science Sichuan Agricultural University,Ya’an,Sichuan,625014,P.R.China [2]Sichuan Normal University,Chengdu 610068,P.R.China

出　　处：《Organic Chemistry Frontiers》2022年第5期1315-1320,共6页有机化学前沿（英文）

基　　金：We appreciate Sichuan Agricultural University for financial support.

摘　　要：The catalyticα-C–H fluorination of aryl acetic acids was achieved with good functional group tolerance in the presence of a boron catalyst.A series ofα-fluoro aryl acetic acids were obtained in a single step with high yields(up to 96%).The catalytic reaction was employed for the synthesis of bioactive molecules and the modification of profen drugs.Moreover,the reaction could be performed on a gram scale.Further transformations were carried out.

关 键 词：CATALYST acetic CATALYZED 

分 类 号：O62[理学—有机化学]