Palladium-catalyzed alkynylative[5+1]carboannulation of 1,3-diarylprop-2-yn-1-yl acetates with terminal alkynes enabled by C-H functionalization  

作　　者：Jiang-Xi Yu Li-Jun Wu Zhi-Qiang Wang Zhi-Feng Xu Jin-Heng Li 

机构地区：[1]Key Laboratory of Functional Meta-Organic Compounds of Hunan Province,Key Laboratory of Functional Organometallic Materials(University of Hunan Province),Hengyang Normal University,Hengyang 421008,China [2]College of Sciences,Central South University of Forestry and Technology,Changsha,410004,China [3]Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle,Nanchang Hangkong University,Nanchang 330063,China [4]School of Chemistry and Chemical Engineering,Henan Normal University,Xinxiang,Henan 475004,China

出　　处：《Organic Chemistry Frontiers》2022年第5期1389-1394,共6页有机化学前沿（英文）

基　　金：We thank the National Natural Science Foundation of China(No.21625203 and 21871126);the Open Research Fund of School of Chemistry and Chemical Engineering,Henan Normal University(No.2021ZD01)for financial support.

摘　　要：A new method for the synthesis of 3-ethynyl-1-methylene-1,2-dihydronaphthalenes via copper-pro-moted palladium-catalyzed intermolecular alkynylative[5+1]carboannulation of 1-arylphenyl-prop-2-yn-1-yl acetates involving C–H functionalization is described.Two terminal alkyne molecules serve as an alkynylation reagent and a one-carbon unit to enable alkynylative[5+1]carboannulation with excellent selectivity control,broad substrate scope and good tolerance of functional groups.

关 键 词：CATALYZED PALLADIUM PALLADIUM 

分 类 号：O62[理学—有机化学]