Synthesis of spirocyclopropylpyrazole derivatives via the cascade reaction of alkylidenecyclopropanes with pyrazolidinones and trifluoroethanol  

作　　者：Mengyang Shen Yuanshuang Xu Xinying Zhang Xuesen Fan 

机构地区：[1]NMPA Key Laboratory for Research and Evaluation of Innovative Drug,Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals,Key Laboratory of Green Chemical Media and Reactions,Ministry of Education,School of Chemistry and Chemical Engineering,Henan Normal University,Xinxiang,Henan 453007,China

出　　处：《Organic Chemistry Frontiers》2022年第5期1410-1416,共7页有机化学前沿（英文）

基　　金：We are grateful to the National Natural Science Foundation of China(U2004189);the Central Plains Science and Technology Innovation Leader Project(224200510009);the Program for Innovative Research Team in Science and Technology in Universities of Henan Province(20IRTSTHN005);the Natural Science Foundation of Henan Province(212300410364);the Henan Key Laboratory of Organic Functional Molecules and Drug Innovation;the 111 Project(D17007)for financial support.

摘　　要：A novel synthesis of spirocyclopropylpyrazole derivatives tethered with a trifluoromethyl unit through an unprecedented cascade reaction of alkylidenecyclopropanes with pyrazolidinones and trifluoroethanol(TFE)has been developed.

关 键 词：ALKYL ETHANOL SPIRO 

分 类 号：O62[理学—有机化学]