光滑念珠菌耐药机制的研究进展  

Research progress on drug resistance mechanism of Candida glabrata

作　　者：徐怡澜 阎澜 XU Yilan;YAN Lan(School of Basic Medicine,Navy Medical University,Shanghai 200433,China;Center for Drug Discovery and Development,School of pharmacy,Navy Medical University,Shanghai 200433,China;National Demonstration Center for Experimental Military Pharmacy Education,Navy Medical University,Shanghai 200433,China)

机构地区：[1]海军军医大学基础医学院,上海200433 [2]海军军医大学药学系军特药研究中心,上海200433 [3]海军军医大学军事药学国家级实验教学示范中心,上海200433

出　　处：《药学实践与服务》2023年第7期393-395,432,共4页Journal of Pharmaceutical Practice and Service

基　　金：国家自然科学基金资助项目(82173867);上海市科技创新行动计划国际科技合作项目(21430713000);上海市浦江人才计划(21PJD081);上海市创新行动计划生物医药领域科技支撑项目(19431901300)。

摘　　要：随着念珠菌病患者中感染光滑念珠菌的比例逐年增加,光滑念珠菌已成为除白念珠菌、热带念珠菌外较为常见的致病念珠菌之一。抗光滑念珠菌的药物种类有限,随之而来的耐药问题日益严重,为临床治疗带来困难。本文综述了光滑念珠菌对唑类、棘白菌素类及多烯类药物的耐药机制。With the increasing proportion of Candida glabrata in patients with candidiasis,C.glabrata has become one of the most common pathogenic Candida in clinical practice.There are limited types of antifungal drugs,and the consequent problem of drug resistance is severely increasing,which brings difficulties to clinical treatment.The resistance mechanisms of C.glabrata to azoles,echinocandins and polyenes were reviewed in this paper.

关 键 词：光滑念珠菌 唑类 棘白菌素类 多烯类 耐药性 

分 类 号：R379.4[医药卫生—病原生物学]