OSMAC策略探索海洋真菌次生代谢产物的研究进展  

AResearch progress of secondary metabolites of marine fungi by OSMAC strategy

作　　者：金嘉悦 方淼森 尹凯波 姜明国 王一兵 strategyJin Jia-yue;Fang Miao-sen;Yin Kai-bo;Jiang Ming-guo;Wang Yi-bing(Guangxi Key Laboratory for Polysaccharide Materials and Modification,School of Marine Sciences and Biotechnology,Guangxi Minzu University,Nanning 530008)

机构地区：[1]广西民族大学海洋与生物技术学院,广西多糖材料与改性重点实验室,南宁530008

出　　处：《中国抗生素杂志》2023年第5期481-491,共11页Chinese Journal of Antibiotics

基　　金：广西科技基地和人才专项(No.桂科AD18281066);广西科技重大专项(No.桂科AA18242026);广西民族大学科研基金资助项目(No.2017KJQD006)。

摘　　要：海洋生态环境(如高盐、高压、低温和寡营养等)以及海洋生物物种间复杂广泛关系赋予了海洋真菌独特的新陈代谢途径及适应机制,因此相比于陆地来源的相同种属真菌,海洋来源真菌能够产生结构独特、丰富多样、生物活性显著的化合物。迄今为止,已经有上万种化合物从海洋真菌中分离出来,但受限于传统培养技术,新结构和活性化合物的发现几率和速度都有所下降。“一株多化合物”(one stain-many compounds,OSMAC)策略是传统培养方法的发展,为寻找新型天然产物提供了新的方法,提高挖掘海洋真菌合成次级代谢产物的能力,逐渐被应用于海洋天然产物的发现。本文对OSMAC策略在海洋真菌次生代谢产物发现及活性研究中的应用进行总结,旨在为提高海洋真菌次生代谢产物的新颖性和多样性,加快先导化合物和生物资源的研究提供参考。Marine ecological environment(such as high salt,high pressure,low temperature,and oligotrophy)and the complex and extensive relationship between marine biological species give marine fungi unique metabolic pathways and adaptation mechanisms.Therefore,compared with the same species of terrestrial fungi,marine-derived fungi can produce compounds with unique structure,rich diversity,and significant biological activity.So far,tens of thousands of compounds have been isolated from marine fungi,but limited by traditional culture techniques,the probability and speed of discovery of new structures and active compounds have declined.The"One Stain-Many Compounds"(OSMAC)strategy is the development of traditional culture methods,which provides a new method for finding new natural products and improves the ability of mining marine fungi to synthesize secondary metabolites.In this paper,the application of OSMAC strategy in the discovery and activity study of marine fungal secondary metabolites is summarized,aiming to provide a reference for improving the novelty and diversity of marine fungal secondary metabolites and accelerating the research of lead compounds and biological resources.

关 键 词：OSMAC策略 次生代谢产物 海洋真菌 沉默基因激活 生物活性 

分 类 号：R914.4[医药卫生—药物化学]