Ductular reaction in non-alcoholic fatty liver disease:When Macbeth is perverted  

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作  者:Yang-Huan He Jia-Xing Pan Lei-Ming Xu Ting Gu Yuan-Wen Chen 

机构地区:[1]Department of Gastroenterology and Department of Geriatrics,Huadong Hospital Affiliated to Fudan University,Shanghai 200040,China [2]Department of Gastroenterology,Xinhua Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200092,China [3]Department of Gastroenterology,School of Medicine,Xinhua Hospital,Shanghai Jiaotong University,School of Medicine,Shanghai 200092,China [4]Department of Gastroenterology,Huadong Hospital Affiliated to Fudan University,Shanghai 200040,China

出  处:《World Journal of Hepatology》2023年第6期725-740,共16页世界肝病学杂志(英文版)(电子版)

基  金:the National Natural Science Foundation of China,No.81970511&82270620.

摘  要:Non-alcoholic fatty liver disease(NAFLD)or metabolic(dysfunction)-associated fatty liver disease is the leading cause of chronic liver diseases defined as a disease spectrum comprising hepatic steatosis,non-alcoholic steatohepatitis(NASH),liver fibrosis,cirrhosis,and hepatic carcinoma.NASH,characterized by hepatocyte injury,steatosis,inflammation,and fibrosis,is associated with NAFLD prognosis.Ductular reaction(DR)is a common compensatory reaction associated with liver injury,which involves the hepatic progenitor cells(HPCs),hepatic stellate cells,myofibroblasts,inflammatory cells(such as macrophages),and their secreted substances.Recently,several studies have shown that the extent of DR parallels the stage of NASH and fibrosis.This review summarizes previous research on the correlation between DR and NASH,the potential interplay mechanism driving HPC differentiation,and NASH progression.

关 键 词:Ductular reaction Non-alcoholic steatohepatitis Hepatic progenitor cells Cell differentiation Inflammatory cells Liver fibrosis 

分 类 号:R575[医药卫生—消化系统]

 

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