Adipokines regulate mesenchymal stem cell osteogenic differentiation  

作　　者：Zhong-Hua Xu Chen-Wei Xiong Kai-Song Miao Zhen-Tang Yu Jun-Jie Zhang Chang-Lin Yu Yong Huang Xin-Die Zhou 

机构地区：[1]Department of Orthopedics,Jintan Hospital Affiliated to Jiangsu University,Changzhou 213200,Jiangsu Province,China [2]Department of Orthopedics,The Affiliated Changzhou Second People’s Hospital of Nanjing Medical University,Changzhou 213000,Jiangsu Province,China [3]Changzhou Medical Center,Nanjing Medical University,Changzhou 213000,Jiangsu Province,China [4]Department of Orthopedics,Gonghe County Hospital of Traditional Chinese Medicine,Hainan Tibetan Autonomous Prefecture 811800,Qinghai Province,China

出　　处：《World Journal of Stem Cells》2023年第6期502-513,共12页世界干细胞杂志（英文版）（电子版）

基　　金：the Changzhou Science&Technology Program,No.CJ20210104,CJ20220120,and CJ20210005;Qinghai Province Health System Guidance Plan Project,No.2022-wjzdx-106;Young Talent Development Plan of Changzhou Health commission,No.CZQM2020059;Top Talent of Changzhou“The 14th Five-Year Plan”High-Level Health Talents Training Project,No.2022CZBJ059 and 2022CZBJ061.

摘　　要：Mesenchymal stem cells(MSCs)can differentiate into various tissue cell types including bone,adipose,cartilage,and muscle.Among those,osteogenic differentiation of MSCs has been widely explored in many bone tissue engineering studies.Moreover,the conditions and methods of inducing osteogenic differentiation of MSCs are continuously advancing.Recently,with the gra-dual recognition of adipokines,the research on their involvement in different pathophysiological processes of the body is also deepening including lipid metabolism,inflammation,immune regulation,energy disorders,and bone homeostasis.At the same time,the role of adipokines in the osteogenic differentiation of MSCs has been gradually described more completely.Therefore,this paper reviewed the evidence of the role of adipokines in the osteogenic differentiation of MSCs,emphasizing bone formation and bone regeneration.

关 键 词：Mesenchymal stem cells ADIPOKINES Adipose tissue Osteogenic differentiation OSTEOGENESIS Bone regeneration 

分 类 号：R68[医药卫生—骨科学]