核因子E2相关因子2/血红素加氧酶-1(Nrf2/HO-1)信号通路在酒精性肝病中的作用  

Role of the nuclear factor erythroid 2-related factor 2/heme oxygenase-1 signaling pathway in alcoholic liver disease

作　　者：马成 杨慧[2] MA Cheng;YANG Hui(Graduate School of Shanxi Medical University,Taiyuan 030001,China;Department of Infectious Diseases,The First Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学研究生院,太原030001 [2]山西医科大学第一医院感染病科,太原030001

出　　处：《临床肝胆病杂志》2023年第7期1708-1713,共6页Journal of Clinical Hepatology

基　　金：山西省省筹资金资助留学人员科研项目(2020-168)。

摘　　要：酒精性肝病(ALD)在我国的发病率逐年上升,国民的疾病负担日益增加。肝细胞的氧化应激反应是ALD的重要致病机制。核因子E2相关因子2/血红素加氧酶-1(Nrf2/HO-1)信号通路是人体重要的内源性抗氧化应激通路,在氧化应激作用下,Nrf2被激活并发挥其转录活性诱导HO-1高表达。HO-1是体内重要的氧化应激反应蛋白,与其血红素酶解产物(胆红素、CO、铁)共同发挥着抗炎、抗氧化及调控细胞凋亡的作用。本文将对近年来Nrf2/HO-1信号通路在ALD中的研究进展进行综述,力求为ALD的发生发展寻找理论依据及治疗切入点。The incidence rate of alcoholic liver disease(ALD)is increasing year by year China,and there is a gradual increase in disease burden among Chinese people.Oxidative stress response in hepatocytes is an important pathogenic mechanism of ALD.The nuclear factor erythroid 2-related factor 2(Nrf2)/heme oxygenase-1(HO-1)signaling pathway is an important endogenous anti-oxidative stress pathway in the body,and Nrf2 is activated in response to oxidative stress and exerts its transcriptional activity to induce high HO-1 expression.HO-1 is an important oxidative stress response protein and plays a role in anti-inflammation,anti-oxidation,and cell apoptosis regulation together with heme hydrolysis products(bilirubin,carbon monoxide,and iron).This article reviews the research advances in the role of the Nrf2/HO-1 signaling pathway in ALD in recent years,so as to find a theoretical basis for the development and progression of ALD and an entry point for treatment.

关 键 词：肝疾病 酒精性 NF-E2相关因子2 血红素加氧酶-1 信号传导 

分 类 号：R575.5[医药卫生—消化系统]